Exercise treatment for major depression: Maintenance of therapeutic benefit at 10 months
Exercise treatment for major depression: Maintenance of therapeutic benefit at 10 months
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DOI：
10.1097/00006842-200009000-00006
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发表时间：
2000-09-01
影响因子：
3.3
通讯作者：
Krishnan, KR
中科院分区：
文献类型：
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作者：
Babyak, M;Blumenthal, JA;Krishnan, KR
目的：本研究的目的是评估156名成年重度抑郁症（MDD）志愿者在完成一项研究6个月后的状态，在这项研究中，他们被随机分配到一个为期4个月的有氧运动，舍曲林治疗，或运动和舍曲林的组合。研究方法：抑郁症的存在和严重程度进行了评估，通过临床访谈使用诊断访谈时间表和汉密尔顿抑郁量表（HRSD）和自我报告使用贝克抑郁量表。在基线、治疗4个月后和治疗结束后6个月（10个月后）进行评估。结果如下：4个月后，所有三组患者均表现出显著改善;缓解参与者（即不再符合MDD诊断标准且HRSD评分
Objective: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy, or a combination of exercise and sertraline. Methods: The presence and severity of depression were assessed by clinical interview using the Diagnostic Interview Schedule and the Hamilton Rating Scale for Depression (HRSD) and by self-report using the Beck Depression Inventory. Assessments were performed at baseline, after 4 months of treatment, and 6 months after treatment was concluded tie, after 10 months). Results: After 4 months patients in all three groups exhibited significant improvement; the proportion of remitted participants (ie, those who no longer met diagnostic criteria for MDD and had an HRSD score