The first biosynthetic studies of the azinomycins: acetate incorporation into azinomycin B
The first biosynthetic studies of the azinomycins: acetate incorporation into azinomycin B
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DOI：
10.1039/b400093e
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发表时间：
2004-04-21
影响因子：
4.9
通讯作者：
Lowden, PAS
中科院分区：
文献类型：
--
作者：
Corre, C;Lowden, PAS
C-13-标记的乙酸酯有效地标记抗肿瘤天然产物azinomycin B，揭示了萘甲酸酯片段的聚酮化合物来源，苏氨酸是冷片段的可能前体，α-酮戊二酸酯是氮丙啶片段的可能前体。
C-13-Labelled acetate efficiently labels the antitumour natural product azinomycin B, revealing a polyketide origin for the naphthoate fragment, that threonine is the probable precursor of the cool fragment, and that alpha-ketoglutarate is a probable precursor of the aziridine fragment.