Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997
Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997
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DOI：
10.1086/314903
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发表时间：
1999-08-01
影响因子：
6.4
通讯作者：
Fukuda, K
中科院分区：
文献类型：
--
作者：
Mounts, AW;Kwong, H;Fukuda, K
1997年5月，香港一名3岁男童死于与甲型H5N1流感病毒感染有关的呼吸道疾病，这是已知的首例人类感染这种病毒的病例。11月和12月又发生了另外17起病例。对其中15名因甲型H5N1流感住院的患者进行了病例对照研究，采用与年龄、性别和邻居相匹配的对照来确定疾病的危险因素。在发病前一周内接触活家禽(通过走访零售家禽摊档或售卖活家禽的市场)与H5N1疾病显著相关(病例与对照病例的29%，优势比为4.5P=0.045)，相比之下，旅行、进食或配制家禽产品、最近接触呼吸道疾病患者，包括已知感染甲型H5N1流感的人，与H5N1疾病无关。
In May 1997, a 3-year-old boy in Hong Kong died of a respiratory illness related to influenza A (H5N1) virus infection, the first known human case of disease from this virus. An additional 17 cases followed in November and December. A case-control study of 15 of these patients hospitalized for influenza A (H5N1) disease was conducted using controls matched by age, sex, and neighborhood to determine risk factors for disease. Exposure to live poultry (by visiting either a retail poultry stall or a market selling live poultry) in the week before illness began was significantly associated with H5N1 disease (64% of cases vs. 29% of controls, odds ratio, 4.5, P = .045), By contrast, travel, eating or preparing poultry products, recent exposure to persons with respiratory illness, including persons with known influenza A (H5N1) infection, were not associated with H5N1 disease.