Curcumin-incorporated albumin nanoparticles and its tumor image
Curcumin-incorporated albumin nanoparticles and its tumor image
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DOI：
10.1088/0957-4484/26/4/045603
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发表时间：
2015-01
期刊：
影响因子：
3.5
通讯作者：
Guangming Gong;Qinqin Pan;Kaikai Wang;Rongchun Wu;Yong Sun;Ying Lu
中科院分区：
文献类型：
--
作者：
Guangming Gong;Qinqin Pan;Kaikai Wang;Rongchun Wu;Yong Sun;Ying Lu
白蛋白是疏水性药物的理想载体。以β-巯基乙醇（β-ME）为诱导剂，以姜黄素（CCM）为桥连剂，制备了人血清白蛋白（HSA）-姜黄素（CCM）纳米粒。HSA-CCM纳米粒在组装过程中发生荧光猝灭和构象变化。二硫键和疏水相互作用可能在组装中起关键作用。HSA-CCM纳米颗粒的大小约为130 nm，CCM的溶解度增加了500倍以上。HSA-CCM纳米粒可聚集在肿瘤细胞的胞浆中，并靶向肿瘤组织。因此，β-ME变性法制备的HSA纳米粒是一种很有前途的纳米载体，可以作为化疗药物和成像探针等疏水性物质的载体。
Albumin is an ideal carrier for hydrophobic drugs. This paper reports a facile route to develop human serum albumin (HSA)–curcumin (CCM) nanoparticles, in which β-mercaptoethanol (β-ME) acted as an inducer and CCM acted as a bridge. Fluorescence quenching and conformational changes in HSA–CCM nanoparticles occurred during assembly. Disulfide bonds and hydrophobic interactions may play a key role in assembly. HSA–CCM nanoparticles were about 130 nm in size, and the solubility of CCM increased by more than 500 times. The HSA–CCM nanoparticles could accumulate at the cytoplasm of tumor cells and target the tumor tissues. Therefore, HSA nanoparticles fabricated by β-ME denaturation are promising nanocarriers for hydrophobic substances from chemotherapy drugs to imaging probes.