Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats
Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats
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DOI：
10.1016/j.ejheart.2008.03.002
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发表时间：
2008-05-01
影响因子：
18.2
通讯作者：
Yamamoto, Kazuhiro
中科院分区：
文献类型：
--
作者：
Nishio, Mayu;Sakata, Yasushi;Yamamoto, Kazuhiro
背景：β受体阻滞剂治疗是收缩性心力衰竭的既定治疗策略。然而，其对舒张性心力衰竭（DHF）的益处尚存在争议。目的：本研究旨在探讨比索洛尔对DHF的影响。方法和结果：Dahl盐敏感大鼠从6周龄开始饲喂8% NaCl饮食，作为DHF模型大鼠，在13周龄时分为三组。一组用比索洛尔 12.5 mg/kg/天治疗（低剂量组，n = 18），一组用比索洛尔 250 mg/kg/天治疗（高剂量组，n = 18），还有一个未治疗组（未治疗组，n = 18）。高剂量组的存活率最好。高剂量组的左心室肥厚和心肌中促炎细胞因子的表达显着减弱，但低剂量组则没有，并且高剂量组氧化应激受到最大程度的抑制。电子自旋共振测量表明，比索洛尔具有强大的清除能力，并且比索洛尔减弱了过氧化物酶体增殖激活受体共激活剂的下调，这是线粒体活性氧解毒系统中的重要元素。 结论：β受体阻滞剂给药，特别是高剂量时，至少部分通过减轻炎症变化和氧化应激，提高了DHF模型的存活率。 (C) 2008 年欧洲心脏病学会。由 Elsevier B.V. 出版。保留所有权利。
Background: beta-blocker therapy is an established therapeutic strategy for systolic heart failure. However, its benefits in diastolic heart failure (DHF) are controversial.Aims: This study was designed to investigate the effects of bisoprolol on DHF.Methods and results: Dahl salt-sensitive rats fed on 8% NaCl diet from age 6 weeks, DHF model rats, were divided into three groups at age 13 weeks. One group was treated with bisoprolol 12.5 mg/kg/day (Low dose group, n = 18), one group was treated with bisoprolol 250 mg/kg/day (High dose group, n = 18), and there was also an untreated group (Untreated group, n = 18). The survival rate was best in the High dose group. Left ventricular hypertrophy and the expression of proinflammatory cytokines in the myocardium were significantly attenuated in the High dose group, but not in the Low dose group, and oxidative stress was most suppressed in the High dose group. Measurement with electron spin resonance revealed that bisoprolol had a potent scavenging ability, and bisoprolol attenuated the down-regulation of peroxisome proliferation-activated receptor coactivator-lot, an important element in the mitochondrial reactive oxygen species detoxification system.Conclusion: beta-blocker administration, particularly at high dose, improved the survival rate of the DHF model, at least partly through the attenuation of inflammatory changes and oxidative stress. (C) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.