Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
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DOI：
10.1038/ni.2477
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发表时间：
2013-01-01
影响因子：
30.5
通讯作者：
Massberg, Steffen
中科院分区：
文献类型：
--
作者：
Stark, Konstantin;Eckart, Annekathrin;Massberg, Steffen
组织内的协调导航对于先天免疫系统的细胞到达炎症过程的部位是必不可少的，但是所涉及的信号还不完全清楚。在这里，我们证明了NG 2（+）周细胞控制的模式和效力的间质迁移的白细胞在体内。为了响应炎症介质，周细胞上调粘附分子ICAM-1的表达，并释放趋化因子MIF。小动脉和毛细血管周细胞吸引和相互作用后，从毛细血管后小静脉外渗髓性白细胞，“指导”他们与模式识别和运动程序。抑制MIF可中和NG 2（+）周细胞向髓系白细胞提供的迁移信号。因此，我们的研究结果确定了NG 2（+）周细胞作为先天性免疫反应的活性成分的一个先前未知的作用，这支持了外渗的中性粒细胞和巨噬细胞的免疫监视和效应功能。
Coordinated navigation within tissues is essential for cells of the innate immune system to reach the sites of inflammatory processes, but the signals involved are incompletely understood. Here we demonstrate that NG2(+) pericytes controlled the pattern and efficacy of the interstitial migration of leukocytes in vivo. In response to inflammatory mediators, pericytes upregulated expression of the adhesion molecule ICAM-1 and released the chemoattractant MIF. Arteriolar and capillary pericytes attracted and interacted with myeloid leukocytes after extravasating from postcapillary venules, 'instructing' them with pattern-recognition and motility programs. Inhibition of MIF neutralized the migratory cues provided to myeloid leukocytes by NG2(+) pericytes. Hence, our results identify a previously unknown role for NG2(+) pericytes as an active component of innate immune responses, which supports the immunosurveillance and effector function of extravasated neutrophils and macrophages.