Increased Subthalamic Nucleus Deep Brain Stimulation Amplitude Impairs Inhibitory Control of Eye Movements in Parkinson's Disease.
Increased Subthalamic Nucleus Deep Brain Stimulation Amplitude Impairs Inhibitory Control of Eye Movements in Parkinson's Disease.
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DOI：
10.1111/ner.13476
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发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
David FJ
中科院分区：
文献类型：
--
作者：
Munoz MJ;Goelz LC;Pal GD;Karl JA;Metman LV;Sani S;Rosenow JM;Ciolino JD;Kurani AS;Corcos DM;David FJ
帕金森病 (PD) 患者的双侧丘脑底核深部脑刺激 (STN DBS) 可能会对眼球运动抑制控制产生不利影响。为了研究双侧 STN DBS 的有害影响，我们检查了在抗眼跳任务期间操纵 STN DBS 幅度对抑制控制的影响。反眼跳任务期间的眼跳错误率，即方向错误，表明抑制控制受损。我们假设随着刺激幅度的增加，眼跳错误率会增加。 10 名接受双侧 STN DBS 的参与者在 12 小时过夜停用抗帕金森病药物后，完成了六种不同刺激幅度（包括零幅度）的抗眼跳任务。我们发现，眼跳错误率随着刺激幅度的增加而增加（p<0.01）。此外，随着模型激活组织体积 (VTA) 和 STN 重叠的减少，前跳错误率增加，但这种关系取决于刺激幅度 (p=0.04)。我们的研究结果表明，较高的刺激幅度设置可以调节抑制控制。刺激幅度影响的一些个体差异可以通过主动接触位置和 VTA-STN 重叠来解释。如果活动接触点落在 STN 之外并导致 VTA-STN 重叠较小，则较高的刺激幅度更有害。这具有临床意义，因为它可以为 STN DBS 参数的临床优化提供信息。需要进一步的研究来确定刺激幅度对认知其他方面的影响，以及反眼跳任务的抑制控制缺陷是否会对生活质量产生有意义的影响。
Bilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson’s disease (PD) can have detrimental effects on eye movement inhibitory control. To investigate this detrimental effect of bilateral STN DBS, we examined the effects of manipulating STN DBS amplitude on inhibitory control during the antisaccade task. The prosaccade error rate during the antisaccade task, i.e., directional errors, was indicative of impaired inhibitory control. We hypothesized that as stimulation amplitude increased the prosaccade error rate would increase. Ten participants with bilateral STN DBS completed the antisaccade task on six different stimulation amplitudes (including zero amplitude) after a 12-hour overnight withdrawal from antiparkinsonian medication. We found that the prosaccade error rate increased as stimulation amplitude increased (p<0.01). Additionally, prosaccade error rate increased as the modelled volume of tissue activated (VTA) and STN overlap decreased but this relationship depended on stimulation amplitude (p=0.04). Our findings suggest that higher stimulation amplitude settings can be modulatory for inhibitory control. Some individual variability in the effect of stimulation amplitude can be explained by active contact location and VTA-STN overlap. Higher stimulation amplitudes are more deleterious if the active contacts fall outside of the STN and have a resulting smaller VTA-STN overlap. This is clinically significant as it can inform clinical optimization of STN DBS parameters. Further studies are needed to determine stimulation amplitude effects on other aspects of cognition and whether inhibitory control deficits on the antisaccade task result in a meaningful impact on quality of life.
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DOI：
10.3233/jpd-171077
发表时间：
2017
期刊：
Journal of Parkinson's disease
影响因子：
--
作者：
Dayal V;Limousin P;Foltynie T
通讯作者：
Foltynie T
影响因子：
14.5
作者：
Hershey, Tamara;Campbell, Meghan C.;Perlmutter, Joel S.
通讯作者：
Perlmutter, Joel S.
影响因子：
2
作者：
Fischer, B;Weber, H
通讯作者：
Weber, H
影响因子：
2
作者：
Khan, Amad Naseer;Bronstein, Adolfo;Nandi, Dipankar
通讯作者：
Nandi, Dipankar
影响因子：
4.4
作者：
LEICHNETZ, GR
通讯作者：
LEICHNETZ, GR