Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development
Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development
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DOI：
10.1073/pnas.96.7.3781
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发表时间：
1999-03-30
影响因子：
11.1
通讯作者：
Glimcher, LH
中科院分区：
文献类型：
--
作者：
Kim, JI;Li, TS;Glimcher, LH
脊椎动物透镜是由终末分化的纤维细胞和前透镜上皮细胞组成的组织。被称为晶状体蛋白的可溶性蛋白质的丰富的优先表达在透镜中产生透明的折射率梯度。几个转录因子，如Pax 6，Sox 1，和L-Maf已被证明可以调节透镜的发展。在这里，我们表明，缺乏转录因子c-Maf的小鼠是小眼继发于有缺陷的透镜形成，特别是从失败的后透镜纤维伸长。所观察到的晶状体蛋白基因表达的显著损害可能由c-Maf反式激活晶状体蛋白基因启动子的能力来解释。因此，c-Maf是脊椎动物透镜分化所必需的。
The vertebrate lens is a tissue composed of terminally differentiated fiber cells and anterior lens epithelial tells. The abundant, preferential expression of the soluble proteins called crystallins creates a transparent, refractive index gradient in the lens. Several transcription factors such as Pax6, Sox1, and L-Maf have been shown to regulate lens development Here we show that mice lacking the transcription factor c-Maf are microphthalmic secondary to defective lens formation, specifically from the failure of posterior lens fiber elongation. The marked impairment of crystallin gene expression observed is likely explained by the ability of c-Maf to transactivate the crystallin gene promoter, Thus, c-Maf is required for the differentiation of the vertebrate lens.