Mitochondrial protein kinase Cε (PKCε):: emerging role in cardiac protection from ischaemic damage
Mitochondrial protein kinase Cε (PKCε):: emerging role in cardiac protection from ischaemic damage
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DOI：
10.1042/bst0351052
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发表时间：
2007-11-01
影响因子：
3.9
通讯作者：
Mochly-Rosen, D.
中科院分区：
文献类型：
--
作者：
Budas, G. R.;Mochly-Rosen, D.
线粒体介导多种细胞功能，包括能量产生和ROS（活性氧）产生，并有助于信号转导。线粒体也是细胞活力的关键调节因子，并在心脏缺血/再灌注损伤诱导的坏死和凋亡细胞死亡途径中发挥核心作用。PKC（蛋白激酶C）e在保护心脏免于缺血/再灌注的心脏保护信号通路中起关键作用。新出现的证据表明，PKC β的心脏保护作用靶点位于线粒体。提出的PKC β的线粒体靶点包括mitoKATP（线粒体ATP敏感性K+通道），MPTP（线粒体渗透性转换孔）的组分和电子传递链的组分。这篇综述强调了PKCe的线粒体靶点及其在缺血/再灌注损伤中心脏保护信号传导中的可能作用。
Mitochondria mediate diverse cellular functions including energy generation and ROS (reactive oxygen species) production and contribute to signal transduction. Mitochondria are also key regulators of cell viability and play a central role in necrotic and apoptotic cell death pathways induced by cardiac ischaemia/reperfusion injury. PKC (protein kinase C) e plays a critical role in cardioprotective signalling pathways that protect the heart from ischaemia/reperfusion. Emerging evidence suggests that the cardioprotective target of PKC epsilon resides at the mitochondria. Proposed mitochondrial targets of PKC epsilon include mitoKATP (mitochondrial ATP-sensitive K+ channel), components of the MPTP (mitochondrial permeability transition pore) and components of the electron transport chain. This review highlights mitochondrial targets of PKCe and their possible role in cardioprotective signalling in the setting of ischaemia/reperfusion injury.