Mechanistic Studies and Optimisation of a Pd-catalysed Direct Arylation Reaction Using Q1 Phosphine-free Systems
Mechanistic Studies and Optimisation of a Pd-catalysed Direct Arylation Reaction Using Q1 Phosphine-free Systems
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使用 Q1 无膦体系的 Pd 催化直接芳基化反应的机理研究和优化
DOI：
10.1039/c4qo00351a
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Qiao Zhang and Takaki Kanbara
中科院分区：
文献类型：
--
作者：
Junpei Kuwabara;Masaru Sakai;Qiao Zhang and Takaki Kanbara
研究了钯催化的无膦直接芳基化反应的初始步骤，以提供机理见解，从而优化催化反应。基于我们的观察，将Pd（0Ac）2催化剂的量减少至1摩尔%，提供了所需产物的良好产率以及副产物量的减少。
The initial step of a Pd-catalysed phosphine-free direct arylation reaction was investigated to provide mechanistic insight, leading to optimisation of the catalytic reaction. On the basis of our observations, the amount of the Pd(OAc)2 catalyst was reduced to 1 mol%, affording a good yield of the desired product in combination with a reduction in the amount of by-products.