Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts
Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts
复制标题
DOI：
10.1111/j.1601-0825.2011.01810.x
复制
发表时间：
2011-09-01
期刊：
影响因子：
3.8
通讯作者：
Xu, X.
中科院分区：
文献类型：
--
作者：
Jia, Z-L;Shi, B.;Xu, X.
目的：探讨非综合征性唇裂的危险因素。材料与方法：采用病例对照研究方法，以中国为研究对象，对537例非综合征性唇裂伴/不伴腭裂患儿、176例先天性腭裂患儿和221名正常对照进行问卷调查，以确定与母体营养相关的危险因素。结果：单因素卡方分析筛选出12个与非综合征性唇裂显著相关的因素(P<；0.05)。多因素Logistic回归分析显示，有5个因素与非综合征性唇裂有关，男性和孕期被动吸烟是非综合征性唇裂的危险因素(OR=1.86和11.42；95%CI分别为2.28~2.69和6.87~19.00)，而孕期体重增加和孕期补充叶酸是保护性因素(OR=0.15和0.67；95%可信区间分别为0.034.44~0.6 3和0.44~1.0 0。结论：本研究结果可为中国地区开展唇裂、脑瘫的预防和心理咨询工作提供参考。口腔疾病(2011)17,584-589
OBJECTIVE: To explore the risk factors of non-syndromic orofacial clefts.SUBJECTS AND METHODS: A case-control study was conducted in China, 537 infants born with non-syndromic cleft lip with/without cleft palate, 176 infants born with cleft palate (CP), and 221 normal controls were recruited to participate in a questionnaire based study to identify risk factors related to maternal nutrition.RESULTS: Single-factor Chi-square analysis identified 12 factors as significantly related to non-syndromic orofacial clefts (P < 0.05). Multiple logistic regression showed five of these factors were associated with non-syndromic orofacial clefts, male gender and maternal passive smoking during early pregnancy were risk factors for non-syndromic orofacial clefts (OR = 1.86 and 11.42; 95% CI: 2.28-2.69 and 6.87-19.00, respectively), whereas maternal weight gain during pregnancy and folic acid supplementation during early pregnancy were protective (OR = 0.15 and 0.67; 95% CI: 0.034-0.63 and 0.44-1.00, respectively).CONCLUSIONS: Our data may provide references for cleft lip and CP prevention programs, and counseling programs in China. Oral Diseases (2011) 17, 584-589