On the dynamic nature of positional information
On the dynamic nature of positional information
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DOI：
10.1002/bies.20494
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发表时间：
2006-11-01
期刊：
影响因子：
4
通讯作者：
Reinitz, John
中科院分区：
文献类型：
--
作者：
Jaeger, Johannes;Reinitz, John
形态发生场是胚胎学最基本的概念之一。然而，它们也是定义最模糊的，因为它们由动态的监管过程组成，其确切性质仍然难以捉摸。为了实现对发展领域更严格的定义，刘易斯·沃尔伯特引入了位置信息的概念，他的法国国旗模型说明了这一概念。在这里，我们认为沃尔伯特的位置信息--定义场的静态坐标系--缺乏原始场概念的基本性质。我们展示了数据驱动的数学建模方法现在如何使我们能够以一种与我们以前的理解水平有质的不同的方式来研究监管过程。作为一个例子，我们回顾了我们最近对果蝇黑腹果蝇胚泡胚层基因表达的分析。基于这一分析，我们提出了一个修订的法国国旗，它纳入了果蝇胚芽中模式形成的动态、反馈驱动的性质。
Morphogenetic fields are among the most fundamental concepts of embryology. However, they are also among the most ill-defined, since they consist of dynamic regulatory processes whose exact nature remains elusive. In order to achieve a more rigorous definition of a developmental field, Lewis Wolpert introduced the concept of positional information illustrated by his French Flag model. Here we argue that Wolpert's positional information - a static coordinate system defining a field - lacks essential properties of the original field concept. We show how data-driven mathematical modeling approaches now enable us to study regulatory processes in a way that is qualitatively different from our previous level of understanding. As an example, we review our recent analysis of segmentation gene expression in the blastoderm embryo of the fruit fly Drosophila melanogaster. Based on this analysis, we propose a revised French Flag, which incorporates the dynamic, feedback-driven nature of pattern formation in the Drosophila blastoderm.