Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment
Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment
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作者：
Witmer, M. T.;Cho, M.;Kiss, S.
目的孔源性视网膜脱离（RRD）手术治疗前后对视网膜功能的影响.我们调查了急性RRD患者的超宽视野自体荧光（UAF）异常，以提高我们对视网膜功能变化的认识，在手术前后。方法在这项回顾性研究中，我们提出了16例急性，非创伤性RRD的UAF成像结果。术前14眼，术后12眼，使用Optos 200 Tx（Optos）进行成像。黄斑区视网膜脱离12眼（A组），黄斑区视网膜脱离4眼（B组）。术前A组100%的眼和B组75%的眼观察到视网膜脱离的高荧光前缘（HLE）。A组术前通过中心凹的UAF正常（30%），低荧光（50%）或高荧光（20%）。在所有术前发生HLE的患者中，HLE在术后1个月访视时消退。12只眼中有8只（67%）残留分界线。A组9只眼中有4只眼（44%）出现术后颗粒状自体荧光改变，并且与更差的术前结论UAF成像显示RRD的异常，可以很好地划分视网膜脱离的范围，并有助于术前的脱离特征和术后咨询。Eye（2012）26，1209-1216; doi：10.1038/eye.2012.122; 2012年6月22日在线发表
Purpose Rhegmatogenous retinal detachment (RRD) affects the function of the retina before and after surgical repair. We investigated ultra-wide-field autofluorescence (UAF) abnormalities in patients with acute RRD to improve our understanding of the functional changes in the retina before and after surgery.Methods In this retrospective study, we present the UAF imaging findings of 16 patients with acute, non-traumatic RRD. Imaging was obtained with the Optos 200 Tx (Optos) in 14 eyes preoperatively and in 12 eyes postoperatively. Twelve eyes had RRDs that involved the macula (group A), whereas four eyes had macula-sparing RRDs (group B).Results All patients (100%) with bullous retinal detachments demonstrated hypofluorescence over the area of retinal detachment. A hyperfluorescent leading edge (HLE) to the retinal detachment was observed preoperatively in 100% of eyes in group A and 75% of eyes in group B. Preoperative UAF through the fovea of group A eyes was normal (30%), hypofluorescent (50%) or hyperfluorescent (20%). In all patients with a HLE preoperatively, the HLE resolved by the 1-month postoperative visit. A residual line of demarcation remained in 8 of the 12 eyes (67%). In group A eyes, postoperative granular autofluorescent changes were present in four of the nine (44%) eyes, and were associated with worse preoperative (P = 0.04) and postoperative (P = 0.09) visual acuity.Conclusion UAF imaging reveals abnormalities in RRDs that allow excellent demarcation of the extent of the retinal detachment and assist in preoperative characterization of the detachment and postoperative counselling. Eye (2012) 26, 1209-1216; doi:10.1038/eye.2012.122; published online 22 June 2012