Religious Orders Study and Rush Memory and Aging Project.
Religious Orders Study and Rush Memory and Aging Project.
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DOI：
10.3233/jad-179939
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Schneider JA
中科院分区：
文献类型：
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作者：
Bennett DA;Buchman AS;Boyle PA;Barnes LL;Wilson RS;Schneider JA
宗教秩序研究和拉什记忆和衰老项目都是正在进行的纵向临床病理队列研究老化和阿尔茨海默病（AD）。总结过去五年的进展及其对理解神经退行性疾病的意义。这两项研究的参与者都是老年人，他们没有痴呆症，并同意进行详细的纵向临床评估和器官捐赠。上一次审查总结了截至2011年底的调查结果。在这里，我们总结了过去五年的进展和研究结果，并讨论了这些研究如何在未来为衰老和AD提供信息的新方向。我们总结了1）神经生物学与临床AD关系的发现; 2）将危险因素与临床AD联系起来的神经生物学途径; 3）非认知AD表型，包括运动功能和决策; 4）新药发现平台的开发。需要理解和克服多个层面的复杂性，以开发有效的治疗和预防认知衰退和AD痴呆的方法。
The Religious Orders Study and Rush Memory and Aging Project are both ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer’s disease (AD). To summarize progress over the past five years and its implications for understanding neurodegenerative diseases. Participants in both studies are older adults who enroll without dementia and agree to detailed longitudinal clinical evaluations and organ donation. The last review summarized findings through the end of 2011. Here we summarize progress and study findings over the past five years, and discuss new directions for how these studies can inform on aging and AD in the future. We summarize 1) findings on the relation of neurobiology to clinical AD; 2) neurobiologic pathways linking risk factors to clinical AD; 3) non-cognitive AD phenotypes including motor function and decision making; 4) the development of a novel drug discovery platform. Complexity at multiple levels needs to be understood and overcome to develop effective treatments and preventions for cognitive decline and AD dementia.