Fertility potential in thalassemia major women: current findings and future diagnostic tools
Fertility potential in thalassemia major women: current findings and future diagnostic tools
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DOI：
10.1111/j.1749-6632.2010.05583.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Cedars, Marcelle
中科院分区：
文献类型：
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作者：
Singer, Sylvia T.;Sweeters, Nancy;Cedars, Marcelle
对于许多患有地中海贫血的成年女性来说，保持生育能力、预防提前绝经和预测生殖能力变得至关重要。黄体生成素/促卵泡激素（LH/FSH）和雌二醇，通常用于评估地中海贫血的生育潜力，具有较差的预测价值。目前的生殖实践使用卵巢储备测试标志物，尚未在地中海贫血妇女中进行研究。我们研究了26名女性（平均年龄30岁）肝铁浓度（LIC）与生育状况的关系。其中17例（65%）出现原发性或继发性闭经。分别有48%和35%的患者LH/FSH和雌二醇水平低或检测不到，且与年龄、闭经和LIC无关。这进一步解决了利用现有方法评估地中海贫血生育能力的需求，这也将允许未来与MRI垂体铁测量以及早期干预生育能力的相关性。
Preserving fertility, preventing early menopause, and predicting reproductive ability have become crucial for many adult thalassemia major females. Luteinizing hormone/follicle-stimulating hormone (LH/FSH) and estradiol, commonly used for assessment of fertility potential in thalassemia, have a poor predictive value. Current reproductive practice uses markers of ovarian reserve testing, which were not yet studied in thalassemia women. We explored the relationship between liver iron concentration (LIC) and fertility status in 26 females (mean 30 years old). Seventeen (65%) of them experienced primary or secondary amenorrhea. Levels of LH/FSH and estradiol were low or undetectable in 48% and 35% of patients, respectively and did not correlate with age, presence of amenorrhea, and LIC. This further addresses the need for utilization of current available methods for assessment of fertility capacity in thalassemia, which will also allow future correlation with pituitary iron measures by MRI as well as early intervention for fertility preservation.