Plasma Renin Activity and Resting Heart Rate in a Population of Community-Dwelling Japanese: The Tanushimaru Study
Plasma Renin Activity and Resting Heart Rate in a Population of Community-Dwelling Japanese: The Tanushimaru Study
复制标题
DOI：
10.1093/ajh/hpu235
复制
发表时间：
2015-07-01
影响因子：
3.2
通讯作者：
Fukumoto, Yoshihiro
中科院分区：
文献类型：
--
作者：
Adachi, Hisashi;Enomoto, Mika;Fukumoto, Yoshihiro
心脏率是死亡率以及肥胖和糖尿病发展的一个强有力的预测因素。肾素-血管紧张素-醛固酮系统在血压控制和容量平衡中起重要作用。虽然许多研究表明醛固酮与高血压或胰岛素抵抗有关，但心率与血浆肾素活性（PRA）相关的流行病学证据仍然很少。因此，我们调查了心率是否与PRA有关。方法：2009年在Tanushimaru共招募了1，943名接受健康检查的受试者。用放射免疫法测定血浆肾素和醛固酮浓度。PRA和稳态模型评估（HOMA）采用自然对数转换。将受试者按心率分为4组（< 60/min、60-69/min、70-79/min、>= 80/ min），通过校正年龄和性别后的协方差分析，分析PRA与心率之间的关系。校正后的PRA和HOMA指数随着心率的增加而呈显著性变化趋势（P < 0.01），而醛固酮与心率之间无显著性变化趋势（P = 0.26）。多元线性回归分析显示，PRA与心率升高呈显著正相关（P < 0.01），而与醛固酮无关。
BACKGROUNDHeart rate is a strong predictor of mortality and development of obesity and diabetes. The renin-angiotensin-aldosterone system plays an important role in blood pressure control and volume homeostasis. Although many studies have indicated the association between aldosterone and hypertension or insulin resistance, epidemiological evidence of the association of heart rate with plasma renin activity (PRA) remains scant. Therefore, we investigated whether heart rate is associated with PRA.METHODSA total of 1,943 subjects were enrolled, who underwent a health examination in Tanushimaru in 2009. Plasma renin and aldosterone concentrations were measured by radioimmunoassay. PRA and the homeostasis model assessment (HOMA) were used by natural-log transformed. Resting heart rate was measured using electrocardiography.RESULTSWe divided the subjects into four groups by heart rate (< 60/min, 60-69/min, 70-79/min, >= 80/ min), and analyzed an association between PRA and heart rate by analysis of covariance after adjustments for age and sex. The adjusted mean PRA and HOMA index showed a significant trend (P < 0.01) as higher heart rate, although there was no significant trend between aldosterone and heart rate (P = 0.26). In multiple linear regression analysis adjusted for age, sex, systolic blood pressure, HOMA index, and hypertensive medication, PRA was positively and strongly associated with elevated heart rate (P < 0.01).CONCLUSIONSThis epidemiological study demonstrated that PRA, but not aldosterone, is significantly and positively associated with higher resting heart rate in a general population.