Translational research: from basic research to regional biomedical entrepreneurship
Translational research: from basic research to regional biomedical entrepreneurship
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DOI：
10.1007/s11187-022-00676-9
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发表时间：
2022-08-30
影响因子：
6.4
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中科院分区：
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本文考察了转化型研究对美国各地区知识生产和生物医学创业的影响。早些时候，研究人员通过关注学术出版物来调查翻译研究的成果。很少有人注意将转化性研究与生物医学创业联系起来。我们构建了一个基于创业知识溢出理论和创业生态系统方法的分析模型，考察了转化型研究、生物医学专利、临床试验和生物医学创业之间的关系。我们使用与NIH临床和翻译科学奖(CTSA)计划相关的10年来的面板数据，在381个美国大都市统计地区测试了该模型。CTSA似乎增加了NIH小型企业创新研究(SBIR)拨款所代表的生物医学专利和生物医学创业的数量。然而，这些影响的幅度相对较小。路径分析表明，转化性研究对区域生物医学创业的影响并不是通过生物医学专利或临床试验来传递的。旨在加快将研究成果转化为产品/过程的计划能否增加生物医药部门的区域创业精神？转化性研究项目通常解决基础科学和临床试验/商业化之间的差距。我们考察了一个这样的项目，美国国立卫生研究院的S临床和翻译科学奖(CTSA)项目，自2006年以来，该项目已经资助了60多所美国大学和其他机构。我们发现，该计划对区域生物医学创业产生了积极影响。转化研究似乎也增加了地区性生物医学专利的数量。然而，不能说生物医学专利的增加“导致”了更高水平的地区性生物医学创业。政策制定者可以加强努力，提高翻译研究人员的创业意识和倾向，从而提高对翻译研究活动产生的知识的利用。
This paper examines the effect of translational research on knowledge production and biomedical entrepreneurship across U.S. regions. Researchers have earlier investigated the outputs of translational research by focusing on academic publications. Little attention has been paid to linking translational research to biomedical entrepreneurship. We construct an analytical model based on the knowledge spillover theory of entrepreneurship and the entrepreneurial ecosystem approach to examine the relationship between translational research, biomedical patents, clinical trials, and biomedical entrepreneurship. We test the model across 381 U.S. metropolitan statistical areas using 10 years of panel data related to the NIH Clinical and Translational Science Awards (CTSA) program. CTSA appears to increase the number of biomedical patents and biomedical entrepreneurship as proxied by the NIH Small Business Innovation Research (SBIR) grants. However, the magnitudes of the effects are relatively small. Path analysis shows that the effect of translational research on regional biomedical entrepreneurship is not strongly conveyed through biomedical patents or clinical trials. Can programs designed to speed the transformation of research results into products/processes increase regional entrepreneurship in the biomedical sector? Translational research programs generally address the gap between basic science and clinical trials/commercialization. We examine one such program, the National Institutes of Health (NIH)’s Clinical and Translational Science Awards (CTSA) program, that has supported more than 60 U.S. universities and other institutions since 2006. We find that the program has positively affected regional biomedical entrepreneurship. Translational research also appears to increase the number of regional biomedical patents. The increased biomedical patents could not, however, be said to have “caused” the higher levels of regional biomedical entrepreneurship. Policymakers may intensify efforts to improve the utilization of knowledge produced by translational research activity by boosting efforts to enhance the entrepreneurial awareness and inclination of translational researchers.