White Matter Tracts Connected to the Medial Temporal Lobe Support the Development of Mnemonic Control.
White Matter Tracts Connected to the Medial Temporal Lobe Support the Development of Mnemonic Control.
复制标题
DOI：
10.1093/cercor/bhu059
复制
发表时间：
2015-09
期刊：
影响因子：
3.7
通讯作者：
C. Wendelken;Joshua K. Lee;Jacqueline Pospisil;Marcos Sastre;J. M. Ross;S. Bunge;S. Ghetti
中科院分区：
文献类型：
--
作者：
C. Wendelken;Joshua K. Lee;Jacqueline Pospisil;Marcos Sastre;J. M. Ross;S. Bunge;S. Ghetti
在童年时期，记忆控制是推动记忆发展的最重要因素之一，也就是启动和维持引导编码和提取操作的过程的能力。有选择地注意和编码相关刺激的能力是记忆控制的一种特别有用的形式，并且在童年时期经历了显着的改善。我们假设，白色物质束的结构完整性，特别是那些连接内侧颞叶记忆区到其他皮质区，和/或那些连接额叶和顶叶控制区，应该有助于成功的记忆控制。为了验证这一假设，我们在116名7-11岁的儿童和25名年轻人中研究了所选白色物质束的结构完整性与记忆控制的实验测量之间的关系，包括通过编码时的注意力增强记忆。我们观察到钩束的完整性和记忆增强在不同年龄组之间存在正相关关系。在成人中，但不是在儿童中，我们还观察到腹侧扣带束和腹侧穹窿/海马伞的记忆增强和完整性之间的关联。完整的额顶叶束，包括背扣带和上级纵束，是无关的记忆增强。
One of the most important factors driving the development of memory during childhood is mnemonic control, or the capacity to initiate and maintain the processes that guide encoding and retrieval operations. The ability to selectively attend to and encode relevant stimuli is a particularly useful form of mnemonic control, and is one that undergoes marked improvement over childhood. We hypothesized that structural integrity of white matter tracts, in particular those connecting medial temporal lobe memory regions to other cortical areas, and/or those connecting frontal and parietal control regions, should contribute to successful mnemonic control. To test this hypothesis, we examined the relationship between structural integrity of selected white matter tracts and an experimental measure of mnemonic control, involving enhancement of memory by attention at encoding, in 116 children aged 7-11 and 25 young adults. We observed a positive relationship between integrity of uncinate fasciculus and mnemonic enhancement across age groups. In adults, but not in children, we also observed an association between mnemonic enhancement and integrity of ventral cingulum bundle and ventral fornix/fimbria. Integrity of fronto-parietal tracts, including dorsal cingulum and superior longitudinal fasciculus, was unrelated to mnemonic enhancement.