Complexation-induced resolution enhancement of 3D-printed hydrogel constructs
Complexation-induced resolution enhancement of 3D-printed hydrogel constructs
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三维打印水凝胶构建体的络合诱导分辨率增强
DOI：
10.1038/s41467-020-14997-4
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发表时间：
2020-03-09
影响因子：
16.6
通讯作者：
Zhang, Yu Shrike
中科院分区：
文献类型：
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作者：
Gong, Jiaxing;Schuurmans, Carl C. L.;Zhang, Yu Shrike
三维（3D）水凝胶打印使得能够使用编程的自动化过程来生产包含所需结构的体积架构。我们的研究报告了一种独特的分辨率增强方法，完全依赖于水凝胶结构的打印后处理。通过将由亲水性聚离子聚合物网络组成的3D打印图案化水凝胶浸入具有相反净电荷的聚离子溶液中，收缩可以迅速发生，导致与原始图案相比不同程度的尺寸减小。这种由复合凝聚和水排出引起的现象使我们能够减少打印构建体的线性尺寸，同时以细胞类型依赖性方式维持细胞相容性条件。我们预计我们的收缩打印技术将在促进当前3D打印能力方面得到广泛应用，以生成更高分辨率的水凝胶结构，而不必涉及复杂的硬件升级或其他打印参数更改。
Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.