RELATION OF SERUM-CALCIUM CONCENTRATION TO METABOLIC RISK-FACTORS FOR CARDIOVASCULAR-DISEASE
RELATION OF SERUM-CALCIUM CONCENTRATION TO METABOLIC RISK-FACTORS FOR CARDIOVASCULAR-DISEASE
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DOI：
10.1136/bmj.297.6654.960
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发表时间：
1988-10-15
影响因子：
105.7
通讯作者：
LJUNGHALL, S
中科院分区：
文献类型：
--
作者：
LIND, L;JAKOBSSON, S;LJUNGHALL, S
来自超过 18000 名成人参与者的健康筛查调查数据被用来确定血清钙浓度与心血管危险因素高血压、高血糖和高脂血症之间的关系。血压、血清葡萄糖和胆固醇浓度均呈正相关，与年龄、性别、肾功能和肥胖无关。在患有高血压或高血糖的受试者中也发现了危险因素之间的类似关系，而与超重程度无关。这些结果表明可能存在心血管代谢综合征的危险因素。血清钙浓度与收缩压和舒张压以及血糖和胆固醇浓度呈正相关。因此，该综合征的一个共同特征是血清钙浓度升高。血清钙浓度与心血管危险因素之间的关系并不局限于分布的上部，而是在很宽的范围内观察到。钙代谢的变化似乎与高血压、糖耐量受损和高脂血症等代谢综合征有关。
Data from a health screening survey with over 18000 adult participants were used to determine the relations between serum calcium concentration and the cardiovascular risk factors hypertension, hyperglycaemia, and hyperlipidaemia. Blood pressure and serum glucose and cholesterol concentrations were all positively related to each other independent of age, sex, kidney function, and obesity. Similar relations beween the risk factors were found in subjects with hypertension or hyperglycaemia independent of the degree of overweight. These results suggested that there might be a metabolic syndrome of cardiovascular risk factors. Serum calcium concentration was positively related to systolic and diastolic blood pressures and serum glucose and cholesterol concentrations. Thus a common feature in the syndrome is an increased serum calcium concentration. The relations between serum calcium concentrations and the cardiovascular risk factors were not limited to the upper parts of the distribution, being seen over a wide range. Changes in calcium metabolism seem to be related to a metabolic syndrome of hypertension, impaired glucose tolerance, and hyperlipidaemia.