Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms.
Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms.
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慢性和循环性缺氧：通过 HIF-1 和 NF-κB 激活导致癌症慢性炎症：分子机制综述。
DOI：
10.3390/ijms221910701
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发表时间：
2021-10-02
影响因子：
5.6
通讯作者：
Baranowska-Bosiacka I
中科院分区：
文献类型：
--
作者：
Korbecki J;Simińska D;Gąssowska-Dobrowolska M;Listos J;Gutowska I;Chlubek D;Baranowska-Bosiacka I
慢性（持续的，不间断的）缺氧和周期性（间歇的，短暂的）缺氧是恶性肿瘤中发生的两种类型的缺氧。它们都与缺氧诱导因子-1 （HIF-1）和核因子κB （NF-κB）的激活有关，从而引起基因表达的变化。本文详细讨论了这两种转录因子在慢性和循环缺氧中的激活机制以及两种信号通路之间的相互作用。特别关注活性氧（ROS）、活性氮（RNS）与一氧化氮合酶、HIF-1的乙酰化以及MAPK级联作用的重要性。本文还讨论了缺氧在恶性肿瘤慢性低度炎症形成中的重要性。最后，我们讨论了循环缺氧对肿瘤微环境的影响，特别是对VEGF-A、CCL2/MCP-1、CXCL1/GRO-α、CXCL8/IL-8、COX-2和PGE2表达的影响。这些因子诱导血管生成并招募各种细胞进入肿瘤生态位，包括中性粒细胞和单核细胞，它们在肿瘤中转化为参与肿瘤发生的肿瘤相关中性粒细胞（TAN）和肿瘤相关巨噬细胞（TAM）。
Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia are two types of hypoxia occurring in malignant tumors. They are both associated with the activation of hypoxia-inducible factor-1 (HIF-1) and nuclear factor κB (NF-κB), which induce changes in gene expression. This paper discusses in detail the mechanisms of activation of these two transcription factors in chronic and cycling hypoxia and the crosstalk between both signaling pathways. In particular, it focuses on the importance of reactive oxygen species (ROS), reactive nitrogen species (RNS) together with nitric oxide synthase, acetylation of HIF-1, and the action of MAPK cascades. The paper also discusses the importance of hypoxia in the formation of chronic low-grade inflammation in cancerous tumors. Finally, we discuss the effects of cycling hypoxia on the tumor microenvironment, in particular on the expression of VEGF-A, CCL2/MCP-1, CXCL1/GRO-α, CXCL8/IL-8, and COX-2 together with PGE2. These factors induce angiogenesis and recruit various cells into the tumor niche, including neutrophils and monocytes which, in the tumor, are transformed into tumor-associated neutrophils (TAN) and tumor-associated macrophages (TAM) that participate in tumorigenesis.
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影响因子：
6
作者：
Bekes, Erin M.;Schweighofer, Bernhard;Deryugina, Elena I.
通讯作者：
Deryugina, Elena I.
影响因子：
7.4
作者：
Chen WL;Wang CC;Lin YJ;Wu CP;Hsieh CH
通讯作者：
Hsieh CH
DOI：
10.31557/apjcp.2019.20.7.2225
发表时间：
2019-07-01
期刊：
Asian Pacific journal of cancer prevention : APJCP
影响因子：
--
作者：
Abd-Rabou, Ahmed A;Ahmed, Hanaa H
通讯作者：
Ahmed, Hanaa H
影响因子：
3.5
作者：
Bulut, A;Erden, E;Dincol, D
通讯作者：
Dincol, D
影响因子：
4.3
作者：
Bandarra D;Biddlestone J;Mudie S;Müller HA;Rocha S
通讯作者：
Rocha S