Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
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DOI：
10.1016/j.freeradbiomed.2018.12.020
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发表时间：
2019-04-01
影响因子：
7.4
通讯作者：
Wang, Yuqin
中科院分区：
文献类型：
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作者：
Griffiths, William J.;Abdel-Khalik, Jonas;Wang, Yuqin
使用液相色谱-质谱联用衍生化学，我们分析了阿尔茨海默病（n=21），血管性痴呆（n=11），其他神经退行性疾病（n=15，路易体痴呆，n=3，额颞叶痴呆，n=11）和对照组（n=15）患者脑脊液中的氧固醇和异戊烯酸含量。对30种不同的甾醇进行定量，发现胆汁酸前体7 α，25-二羟基-3-氧代胆甾-4-烯-26-酸在阿尔茨海默病患者组的脑脊液中丰度降低。这是唯一的甾醇被发现改变之间的不同群体。
Using liquid chromatography-mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n=21), vascular dementia (n=11), other neurodegenerative diseases (n=15, Lewy bodies dementia, n=3, Frontotemporal dementia, n=11) and controls (n=15). Thirty different sterols were quantified and the bile acid precursor 7a, 25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.