Rapid geographic spread of a methicillin-resistant Staphylococcus aureus strain
Rapid geographic spread of a methicillin-resistant Staphylococcus aureus strain
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DOI：
10.1086/513758
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发表时间：
1997-09-01
影响因子：
11.8
通讯作者：
Nicolle, LE
中科院分区：
文献类型：
--
作者：
Roman, RS;Smith, J;Nicolle, LE
1993年5月，在我们的三级保健教学中心发现了耐甲氧西林金黄色葡萄球菌（MRSA）的爆发，流行性MRSA菌株在医院环境中有效传播，随后的调查表明，该菌株已被最近在印度旁遮普住院3个月的患者引入加拿大西部，并在抵达加拿大后不久被送往不列颠哥伦比亚省农村的一家医院，将患者转移至温哥华的一家医院，随后将一名殖民地患者接触者转移至马尼托巴温尼伯的一家医院，导致MRSA在这两个大型三级护理中心的大爆发，在索引病例到达加拿大的6周内，S.金黄色葡萄球菌凝固酶基因与使用聚合酶链反应方法和脉冲场凝胶电泳证明了该菌株的克隆性，这些爆发再次说明了某些菌株的倾向，金黄色葡萄球菌产生流行性疾病，包括机构内的快速传播，以及抗菌素耐药性问题的全球性。
In May 1993, an outbreak of methicillin-resistant Staphylococcus aureus (MRSA) was identified at our tertiary care teaching center, The epidemic MRSA strain was transmitted efficiently in the hospital environment, Subsequent investigations indicated that the strain had been introduced into western Canada by a patient who had recently been hospitalized for 3 months in the Punjab, India, and had been admitted to a hospital in rural British Columbia shortly after his arrival in Canada, Transfer of the patient to a hospital in Vancouver and subsequent transfer of a colonized patient contact to a hospital in Winnipeg, Manitoba, resulted in major outbreaks of MRSA at these two large tertiary care centers within 6 weeks of the arrival of the index case in Canada, Epidemiological typing of the S. aureus coagulase gene with use of a polymerase chain reaction method and pulsed-field gel electrophoresis documented clonality of this strain, These outbreaks again illustrate both the propensity of certain strains of S. aureus to produce epidemic disease, including rapid spread within the institutional setting, and the global nature of problems with antimicrobial resistance.