Objective Quantification of Spontaneous Retinal Venous Pulsations Using a Novel Tablet-Based Ophthalmoscope.
Objective Quantification of Spontaneous Retinal Venous Pulsations Using a Novel Tablet-Based Ophthalmoscope.
复制标题
使用新型平板检眼镜客观量化自发性视网膜静脉搏动。
DOI：
10.1167/tvst.9.4.19
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发表时间：
2020
影响因子：
3
通讯作者：
Golzan,SMojtaba
中科院分区：
文献类型：
--
作者：
Shariflou,Sahar;Agar,Ashish;Rose,Kathryn;Bowd,Christopher;Golzan,SMojtaba
目的：动态评估视网膜血管特征有助于识别视网膜动脉瘤特异性生物标志物。更具体地说，在青光眼中已经报道了自发性视网膜静脉搏动（SVP）的丧失，但是缺乏现成的工具限制了探索SVP分析在青光眼评估中的全部潜力的能力。智能技术的进步为便携式、非侵入性和廉价的成像方式的发展铺平了道路。通过结合现成的光学元件和智能设备，目前的研究旨在确定是否可以使用一种新的基于平板的检眼镜在青光眼和青光眼suggestions.Methods检测和定量SVP：30例患者，包括21例确诊青光眼（9名男性;平均年龄75±8岁）和9名青光眼嫌疑人（5名男性;平均年龄64±9岁），进行了研究。所有患者均进行眼内压测量、Humphrey视野评估、光学相干断层扫描和10秒视网膜循环视频检查。视网膜血管记录（46场，每秒30帧）进行了分析，以提取SVP amplitudes.Results：SVP检测和定量在100%的青光眼患者和怀疑青光眼使用新的设备。青光眼和疑似青光眼患者的平均SVP振幅分别为42.6%±10.7%和34%± 6.7%，corresponding.Conclusions：我们的研究结果表明，一种新型的基于平板的检眼镜可以帮助记录和客观量化所有患者的SVP。这项研究的结果为SVP的客观评估提供了一种创新的、便携式的、非侵入性的和廉价的解决方案，其在青光眼筛查中可能具有临床相关性。
Purpose: Dynamic assessment of retinal vascular characteristics can aid in identifying glaucoma-specific biomarkers. More specifically, a loss of spontaneous retinal venous pulsations (SVPs) has been reported in glaucoma, but a lack of readily available tools has limited the ability to explore the full potential of SVP analysis in glaucoma assessment. Advancements in smart technology have paved the way for the development of portable, noninvasive, and inexpensive imaging modalities. By combining off-the-shelf optical elements and smart devices, the current study aims to determine whether SVPs can be detected and quantified using a novel tablet-based ophthalmoscope in glaucoma and glaucoma suspects.Methods: Thirty patients, including 21 with confirmed glaucoma (9 men; average age 75±8 years) and 9 glaucoma suspects (5 men; average age 64±9 years), were studied. All patients had intraocular pressure measurements, Humphrey visual field assessment, optical coherence tomography, and a 10-second videoscopy of the retinal circulation. The retinal vasculature recordings (46 field of view at 30 frames per second) were analyzed to extract SVP amplitudes.Results: SVPs were detected and quantified in 100% of patients with glaucoma and those with suspected glaucoma using the novel device. The average SVP amplitudes in glaucoma and glaucoma suspects were 42.6%±10.7% and 34%±6.7%, respectively.Conclusions: Our results suggest that a novel tablet-based ophthalmoscope can aid in documenting and objectively quantifying SVPs in all patients.Translational Relevance: Outcomes of this study provide an innovative, portable, noninvasive, and inexpensive solution for objective assessment of SVPs, which may have clinical relevance in glaucoma screening.