ASSOCIATION OF INDOOR NITROGEN-DIOXIDE WITH RESPIRATORY SYMPTOMS AND PULMONARY-FUNCTION IN CHILDREN
ASSOCIATION OF INDOOR NITROGEN-DIOXIDE WITH RESPIRATORY SYMPTOMS AND PULMONARY-FUNCTION IN CHILDREN
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DOI：
10.1093/oxfordjournals.aje.a116073
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发表时间：
1991-07-15
影响因子：
5
通讯作者：
FERRIS, BG
中科院分区：
文献类型：
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作者：
NEAS, LM;DOCKERY, DW;FERRIS, BG
研究人员对 1983 年至 1988 年间在美国六个城市进行的 1,567 名 7-11 岁白人儿童进行了队列研究，研究了室内二氧化氮对呼吸道症状累积发生率和肺功能水平的影响。在冬季和夏季连续两周内，在三个室内地点进行了为期一周的二氧化氮测量。 家庭年平均二氧化氮浓度被建模为连续变量和四个有序类别。 对室内监测后进行的问卷调查的症状报告进行多元逻辑回归分析表明，家庭年二氧化氮平均值增加 15 ppb 与下呼吸道症状累积发生率增加相关（比值比 (OR) = 1.4，95% 置信区间 (95% CI) 1.1-1.7）。 响应变量表明报告了一种或多种以下症状：伴有喘息的气短发作、慢性喘息、慢性咳嗽、慢性痰或支气管炎。 女孩表现出比男孩更强的关联（OR = 1.7，95% CI 1.3-2.2）（OR = 1.2，95% CI 0.9-1.5）。 肺功能测量分析显示二氧化氮没有一致的影响。 这些结果与之前基于家庭二氧化氮来源分类指标的报告一致，并提供了与儿童家庭中测量的二氧化氮更具体的关联。
The effect of indoor nitrogen dioxide on the cumulative incidence of respiratory symptoms and pulmonary function level was studied in a cohort of 1,567 white children aged 7-11 years examined in six US cities from 1983 through 1988. Week-long measurements of nitrogen dioxide were obtained at three indoor locations over 2 consecutive weeks in both the winter and the summer months. The household annual average nitrogen dioxide concentration was modeled as a continuous variable and as four ordered categories. Multiple logistic regression analysis of symptom reports from a questionnaire administered after indoor monitoring showed that a 15-ppb increase in the household annual nitrogen dioxide mean was associated with an increased cumulative incidence of lower respiratory symptoms (odds ratio (OR) = 1.4, 95% confidence interval (95% CI) 1.1-1.7). The response variable indicated the report of one or more of the following symptoms: attacks of shortness of breath with wheeze, chronic wheeze, chronic cough, chronic phlegm, or bronchitis. Girls showed a stronger association (OR = 1.7, 95% CI 1.3-2.2) than did boys (OR = 1.2, 95% CI 0.9-1.5). An analysis of pulmonary function measurements showed no consistent effect of nitrogen dioxide. These results are consistent with earlier reports based on categorical indicators of household nitrogen dioxide sources and provide a more specific association with nitrogen dioxide as measured in children's homes.