Secular trends in testosterone- findings from a large state-mandate care provider
Secular trends in testosterone- findings from a large state-mandate care provider
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DOI：
10.1186/s12958-020-00575-2
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发表时间：
2020-03-09
影响因子：
4.4
通讯作者：
Shalev, Varda
中科院分区：
文献类型：
--
作者：
Chodick, Gabriel;Epstein, Shdema;Shalev, Varda
美国和欧洲的几项研究表明，从20世纪70年代到21世纪初，男性血清睾酮水平呈下降趋势。然而，据我们所知，最近几年没有发表研究人口水平睾丸激素下降的研究。因此，本研究的目的是研究21世纪世纪第一和第二个十年以色列男性睾酮水平的长期趋势，方法在2006年1月至2019年3月期间对一家大型卫生组织的102，334名男性成员进行了所有事件总睾酮检测。结果在研究期间，大多数年龄组的睾酮水平均呈显著（p < 0.001）的非年龄依赖性下降趋势。结论：在21世纪世纪的第一和第二个十年中，总睾酮有一个非常显著的与年龄无关的下降。这一下降不太可能用肥胖率的上升来解释。
Background Several studies from the US and Europe have shown a population-level decline in serum testosterone in men from 1970's to early 2000's. However, to the best of our knowledge, no study examining population-level decline in testosterone has been published in more recent years. The study objective was therefore to examine secular trends in testosterone levels among Israeli men in the first and second decades of the twenty-first century, Methods All incident total testosterone performed between1/2006 and 3/2019 among 102,334 male members of a large health organization. Results A significant (p < 0.001) and prominent trend of age-independent decline in the testosterone levels was recorded during the study period for most age groups. Conclusions There was a highly significant age-independent decline in total testosterone in the first and second decades of the twenty-first century. The decline was unlikely to be explained by increasing rates of obesity.