ConSeq: the identification of functionally and structurally important residues in protein sequences
ConSeq: the identification of functionally and structurally important residues in protein sequences
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DOI：
10.1093/bioinformatics/bth070
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发表时间：
2004-05-22
期刊：
影响因子：
5.8
通讯作者：
Ben-Tal, N
中科院分区：
文献类型：
--
作者：
Berezin, C;Glaser, F;Ben-Tal, N
ConSeq是一个Web服务器，用于识别蛋白质序列中生物学上重要的残基。参与例如配体结合和蛋白质-蛋白质相互作用的功能上重要的残基通常是进化上保守的，并且最有可能是溶剂可接近的，而蛋白质核心内的保守残基最有可能在维持蛋白质折叠中具有重要的结构作用。因此，估计的进化速率，以及相对溶剂可及性预测，分配给序列中的每个氨基酸;两者随后用于指示具有潜在结构或功能重要性的残基。
Motivation: ConSeq is a web server for the identification of biologically important residues in protein sequences. Functionally important residues that take part, e.g. in ligand binding and protein-protein interactions, are often evolutionarily conserved and are most likely to be solvent-accessible, whereas conserved residues within the protein core most probably have an important structural role in maintaining the protein's fold. Thus, estimated evolutionary rates, as well as relative solvent accessibility predictions, are assigned to each amino acid in the sequence; both are subsequently used to indicate residues that have potential structural or functional importance.