Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction as a Key Step
Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction as a Key Step
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以 Evans-Tishchenko 反应为关键步骤全合成 Hoiamide A
DOI：
10.1021/acs.orglett.9b01735
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发表时间：
2019-07-19
期刊：
影响因子：
5.2
通讯作者：
Ye, Tao
中科院分区：
文献类型：
--
作者：
Guo, Yian;Zhou, Jingjing;Ye, Tao
首次完成了神经毒性环缩酚肽甲酰胺A（I）的全合成。该合成的特征在于在含有五个立体异构中心的β-羟基酮和衍生自苏氨酸的手性醛之间使用Evans-Tishchenko片段偶联。
The first total synthesis of neurotoxic cyclo-depsipeptide hoiamide A (I) has been accomplished. The synthesis features the use of an Evans-Tishchenko fragment coupling between a five-stereogenic-center-containing beta-hydroxyketone and a chiral aldehyde derived from threonine.