Resected adenocarcinoma of the pancreas - 616 patients: Results, outcomes, and prognostic indicators
Resected adenocarcinoma of the pancreas - 616 patients: Results, outcomes, and prognostic indicators
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DOI：
10.1016/s1091-255x(00)80105-5
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发表时间：
2000-11-01
影响因子：
3.2
通讯作者：
Lillemoe, KD
中科院分区：
文献类型：
--
作者：
Sohn, TA;Yeo, CJ;Lillemoe, KD
这项来自单一机构的大样本回顾性研究，探讨了胰腺头部、颈部、钩突、体部或尾部腺癌患者切除术后影响长期生存的因素。在1984年1月至1999年7月（含起止时间）期间，616例胰腺腺癌患者接受了手术切除。对前瞻性收集的数据库进行了回顾性分析。采用单变量和多变量模型来确定影响生存的因素。在616例患者中，526例（85%）因胰腺头部、颈部或钩突腺癌接受了胰十二指肠切除术，52例（9%）因体部或尾部腺癌接受了远端胰腺切除术，38例（6%）因肿瘤广泛累及腺体接受了全胰腺切除术。患者的平均年龄为64.3岁，其中54%为男性，91%为白人。总体围手术期死亡率为2.3%，而术后并发症发生率为30%。术后平均住院时间为11天。肿瘤平均直径为3.2厘米，72%的患者有淋巴结阳性，30%的患者切缘阳性，36%的患者肿瘤分化差。因左侧病变接受远端胰腺切除术的患者肿瘤更大（4.7厘米对3.1厘米，P<...（此处原文似乎不完整）
This large-volume, single-institution review examines factors influencing long-term survival after resection in patients with adenocarcinoma of the head, neck, uncinate process, body or tail of the pancreas. Between January 1984 and July 1999 inclusive, 616 patients with adenocarcinoma of the pancreas underwent surgical resection. A retrospective analysis of a prospectively collected database was performed. Both univariate anti multivariate models were used to determine the factors influencing survival. Of the 616 patients, 526 (85%) underwent pancreaticoduodenectomy for adenocarcinoma of the head, neck, or uncinate process of tile pancreas, 52 (9%) underwent distal pancreatectomy for adenocarcinoma of the body or tail, and 38 (6%) underwent total pancreatectomy for adenocarcinoma extensively involving the gland. The mean age of die patients was 64.3 years, with 54% being male and 91% being white. The overall perioperative mortality rate was 2.3%, whereas the incidence of postoperative complications was 30%. The median postoperative length of stay was 11 days. The mean tumor diameter was 3.2 cm, with 72% of patients having positive lymph nodes, 30% having positive resection margins, and 36% having poorly differentiated tumors. Patients undergoing distal pancreatectomy for left-sided lesions had larger tumors (4.7 vs. 3.1 cm, P