Lack of Association of Glutathione S-transferase M3 Gene Polymorphism with the Susceptibility of Lung Cancer
Lack of Association of Glutathione S-transferase M3 Gene Polymorphism with the Susceptibility of Lung Cancer
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DOI：
10.7314/apjcp.2012.13.9.4465
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发表时间：
2012-01-01
影响因子：
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通讯作者：
Zheng, Bao-Shi
中科院分区：
文献类型：
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作者：
Feng, Xu;Dong, Chun-Qiang;Zheng, Bao-Shi
目的：谷胱甘肽S-转移酶M3（GSTM 3）A/B基因多态性与肺癌发病风险的关系的研究结果仍存在争议。本荟萃分析旨在评估GSTM 3与肺癌风险之间的关系。研究方法：从PubMed、Embase和科克伦图书馆中识别相关性研究，并使用荟萃分析方法纳入和合成符合条件的研究。结果如下：本荟萃分析共纳入8篇GSTM 3 A/B基因多态性与肺癌易感性关系的研究报告，涉及1,854例肺癌患者和1,926例对照。Meta分析未发现GSTM 3 A/B基因多态性与肺癌的相关性（B等位基因：OR = 1.25，95%CI：0.89-1.76，P = 0.20; BB基因型：OR = 1.53，95%CI：0.71-3.32，P = 0.28; AA基因型：OR = 0.85，95%CI：0.85 ~ 3.32，P = 0.28）0.59-1.23，P = 0.39）。结论：GSTM 3 A/B基因多态性与肺癌易感性无关。但GSTM 3 A/B基因多态性与肺癌发病风险的关系有待进一步研究。
Objective: The conclusions of published reports on the relationship between the glutathione S-transferase M3 (GSTM3) A/B gene polymorphism and the risk of lung cancer are still debated. This meta-analysis was performed to evaluate the association between GSTM3 and the risk of lung cancer. Methods: Association investigations were identified from PubMed, Embase, and Cochrane Library, and eligible studies were included and synthesized using a meta-analysis method. Results: Eight reports were included into this meta-analysis for the association of GSTM3 A/B gene polymorphism and lung cancer susceptibility, covering 1,854 patients with lung cancer and 1,926 controls. No association between the GSTM3 A/B gene polymorphism and lung cancer was found in this meta-analysis (B allele: OR = 1.25, 95% CI: 0.89-1.76, P = 0.20; BB genotype: OR = 1.53, 95% CI: 0.71-3.32, P = 0.28; AA genotype: OR = 0.85, 95% CI: 0.59-1.23, P = 0.39). Conclusions: The GSTM3 A/B gene polymorphism is not associated with lung cancer susceptibility. However, more studies on the relationship between GSTM3 A/B gene polymorphism and the risk of lung cancer should be performed in the future.