Relationship of psoriasis severity to obesity using same-gender siblings as controls for obesity
Relationship of psoriasis severity to obesity using same-gender siblings as controls for obesity
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DOI：
10.1111/j.1365-2230.2008.02791.x
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发表时间：
2009-03-01
影响因子：
4.1
通讯作者：
Cohen, J. B.
中科院分区：
文献类型：
--
作者：
Murray, M. L.;Bergstresser, P. R.;Cohen, J. B.
背景银屑病是一种受遗传和环境因素影响的多因素疾病。一些共病的条件，如吸烟，抑郁症和肥胖症已被发现与牛皮癣。本研究以同性别同胞为对照，探讨了银屑病与肥胖的关系，并通过体表面积（BSA）和医师总体评估（PGA）确定了体重指数（BMI）与银屑病严重程度之间的相关性。总共调查了88名接受银屑病门诊治疗的患者的人口统计学信息，银屑病史，社会史，个人和家族病史，他们是否有同性别的同胞兄弟姐妹，如果有，兄弟姐妹的年龄，体重和身高。记录每例患者的身高、体重、PGA评分和受银屑病影响的BSA百分比。计算每例患者及其同性别同胞的BMI。银屑病严重程度与BMI呈正相关，PGA评分随BMI增加而增加（斯皮尔曼相关系数r（s）= 0.29，P = 0.007）。BMI与BSA%呈正相关，r（s）= 0.24，P = 0.02。银屑病患者和同性别同胞对照组之间的BMI在女性中存在显著差异（平均值± SD分别为30.2 ± 10.2和27.6 ± 7.3 kg/m2，P = 0.02），但在男性中无显著差异。在这项研究中，发现银屑病的严重程度与肥胖程度有关。使用同性兄弟姐妹作为肥胖和银屑病易感性的遗传控制，银屑病患者更有可能具有较高的BMI，特别是女性。这项研究强调了治疗整个患者和鼓励健康生活的必要性，例如保持适当的体重，适当的饮食习惯和锻炼。这项研究的局限性包括入组的患者数量相对较少，根据患者提供的信息计算的兄弟姐妹BMI可能不准确，以及缺乏有关饮食习惯，运动和生活方式的信息。
Background. Psoriasis is a multifactorial disease affected by both genetic and environmental factors. Several comorbid conditions, such as smoking, depression and obesity have been found to be associated with psoriasis. This study addressed the association of psoriasis and obesity using same-gender full siblings as controls, correlating between body mass index (BMI) and severity of psoriasis as determined by body surface area (BSA) and the Physician's Global Assessment (PGA).Methods. In total, 88 patients undergoing outpatient treatment for psoriasis were surveyed for demographic information, psoriasis history, social history, personal and family medical history, whether they had a same-gender full sibling and if so, the age, weight and height of the sibling. Height, weight, PGA scores and percentage of BSA affected by psoriasis, were recorded for each patient. BMI was calculated for each patient and their same-gender full sibling.Results. A positive association between psoriasis severity and BMI was found. PGA score increased with BMI (Spearman's correlation, r(s) = 0.29, P = 0.007). There was also a positive correlation between BMI and BSA%, r(s) = 0.24, P = 0.02. A significant difference in BMI between patients with psoriasis and the same-gender full sibling control was seen for women (mean +/- SD 30.2 +/- 10.2 vs. 27.6 +/- 7.3 kg/m(2), respectively, P = 0.02), but not for men.Conclusion. In this study, psoriasis severity was found to be related to the level of obesity. Using same-gender siblings as genetic controls for predisposition to both obesity and psoriasis, patients with psoriasis were more likely to have a higher BMI, particularly for women. This study reinforces the need to treat the whole patient and to encourage healthy living, such as maintaining an appropriate weight, proper eating habits and exercise. Limitations of this study include the relatively small number of patients enrolled, potential inaccuracies in sibling BMIs calculated from information provided by patients, and a lack of information about dietary habits, exercise and lifestyle.