Basilar artery blood flow velocity changes in patients with panic disorder following 35% carbon dioxide challenge
Basilar artery blood flow velocity changes in patients with panic disorder following 35% carbon dioxide challenge
复制标题
DOI：
10.1016/j.pnpbp.2006.08.004
复制
发表时间：
2007-01-30
影响因子：
5.6
通讯作者：
Kutluk, Kursad
中科院分区：
文献类型：
--
作者：
Alkin, Tunc;Tural, Umit;Kutluk, Kursad
目的：比较惊恐障碍患者与健康人在二氧化碳(CO2)刺激后即刻和安静时的平均基底动脉血流速度(BABFV)，并探讨治疗对BABFV的影响。采用视觉模拟焦虑量表评价35%CO2吸入对患者焦虑的影响。应用经颅多普勒超声监测帕罗西汀治疗前和治疗4周后静息状态和35%CO激发后10、20、30、60、90、120 S时的平均BABFV。结果：两组患者的基底动脉对CO2吸入的血流动力学反应模式有显著差异。CO，在惊恐患者中迅速触发了基底动脉的血流速度，但在健康对照中则不是。惊恐患者BABFV恢复正常的平均时间明显较长。帕罗西汀治疗4周后，35%CO2吸入后BABFV平均值较治疗前显著降低。结论：惊恐障碍患者存在脑调节机制受损，表现为BABFV对吸入CO的反应特征发生改变。帕罗西汀治疗减少了CO挑战后患者BABFV的增加。(C)2006 Elsevier Inc.保留所有权利。
Purpose: We compared the mean basilar artery blood flow velocity (BABFV) between patients with panic disorder and healthy subjects both at rest and immediately following carbon dioxide (CO2) challenge, and examined the effects of treatment on BABFV.Methods: Twenty four patients with panic disorder with or without agoraphobia and 12 healthy comparison subjects were studied. Visual Analog Anxiety Scale was used to evaluate the anxiogenic effect of 35% CO2 inhalation. Mean BABFV was monitored using transcranial Doppler ultrasonography at rest and 10, 20, 30, 60, 90, 120 s after 35% CO, challenge both before and after four weeks treatment with paroxetine.Results: The hemodynamic response pattern of basilar artery to CO2 inhalation was significantly different between two groups. CO, rapidly triggered blood flow velocity in basilar artery amongst panic patients but not in healthy comparisons. The mean time to normalization of BABFV was significantly longer in panic patients. Four weeks of treatment with paroxetine led to a significantly reduced mean BABFV after 35% CO2 inhalation in comparison with pretreatment.Conclusions: Patients with panic disorder had impaired cerebral regulatory mechanisms observed as a change in response characteristics in BABFV in response to CO, inhalation. Treatment with paroxetine reduced the increase of BABFV seen in patients after the CO, challenge. (c) 2006 Elsevier Inc. All rights reserved.