Endowing Osseointegration Ability to Bioinert Alumina by Carbonate Apatite Coating
Endowing Osseointegration Ability to Bioinert Alumina by Carbonate Apatite Coating
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DOI：
10.1016/j.surfin.2022.102617
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发表时间：
2022-12
影响因子：
6.2
通讯作者：
Koichiro Hayashi;K. Ishikawa
中科院分区：
文献类型：
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作者：
Koichiro Hayashi;K. Ishikawa
使用氧化铝假体进行翻修的主要原因是假体的无菌性松动。为了防止假体松动，赋予生物惰性氧化铝成骨能力被认为是一种有效的方法。因此，我们开发了一种含碳酸磷灰石的氧化铝基质，并评估了其早期与骨结合的有效性。使用以下程序用碳酸磷灰石涂覆氧化铝基底：（1）通过碱性水热处理蚀刻氧化铝基底;（2）蚀刻的氧化铝基底的碳酸钙涂层;和（3）通过磷酸盐化将碳酸钙涂层的组成转化为碳酸磷灰石。碳磷灰石涂层与氧化铝基体的拉伸结合强度为17.6MPa，符合国际标准化组织的标准。与蚀刻氧化铝基质的结果相反，碳酸磷灰石涂层氧化铝基质促进间充质干细胞的增殖和成骨分化，并诱导矿化。此外，与蚀刻的氧化铝基质相比，碳酸磷灰石涂层氧化铝基质在植入后4周强烈粘附到兔胫骨。碳酸磷灰石涂层氧化铝基板的骨的接触面积和粘附强度分别约为蚀刻氧化铝基板的19倍和6倍。因此，碳酸磷灰石涂层可能有助于防止氧化铝假体松动。
The main reason for revision arthroplasty with an alumina-based prosthesis is aseptic loosening of the prosthesis. To prevent loosening of the prosthesis, endowing bioinert alumina with osteogenic ability is deemed an effective approach. Hence, we developed an alumina substrate with carbonate apatite and evaluated its effectiveness for early binding to the bone. Alumina substrates were coated with carbonate apatite using the following procedures: (1) etching the alumina substrate by alkaline hydrothermal treatment; (2) calcium carbonate coating of the etched alumina substrate; and (3) composition conversion of calcium carbonate coating into carbonate apatite by phosphatization. The tensile bond strength of carbonate apatite coating to alumina substrate was 17.6 MPa, which satisfied the criteria defined by the International Organization for Standardization. Contrary to the results of etched alumina substrates, the carbonate apatite-coated alumina substrates promoted the proliferation and osteogenic differentiation of mesenchymal stem cells and induced mineralization. Furthermore, the carbonate apatite-coated alumina substrates strongly adhered to the rabbit tibia 4 weeks after implantation compared to the etched alumina substrates. The contact area and adhesion strength of carbonate apatite-coated alumina substrates to bone were approximately 19- and 6-fold higher than those of etched alumina substrates, respectively. Thus, carbonate apatite coating may contribute to preventing the loosening of alumina prostheses.