Adipose tissue dysfunction and metabolic disorders: Is it possible to predict who will develop type 2 diabetes mellitus? Role of markErs in the progreSsion of dIabeteS in obese paTIeNts (The RESISTIN trial)
Adipose tissue dysfunction and metabolic disorders: Is it possible to predict who will develop type 2 diabetes mellitus? Role of markErs in the progreSsion of dIabeteS in obese paTIeNts (The RESISTIN trial)
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DOI：
10.1016/j.cyto.2019.154947
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发表时间：
2020-03-01
期刊：
影响因子：
3.8
通讯作者：
Maffioli, Pamela
中科院分区：
文献类型：
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作者：
Derosa, Giuseppe;Catena, Gabriele;Maffioli, Pamela
这项研究的目的是评估是否有一些代谢参数的差异在肥胖的人会发展为糖尿病和那些不会发展为糖尿病。我们招募了959名肥胖、糖耐量正常的门诊患者，不论男女，并对他们进行了8年的评估。我们评估：体重指数（BMI）、腰围（WC）、空腹血糖（FPG）、空腹血浆胰岛素（FPI）、稳态模型评估（HOMA）指数、血压、血脂、脂蛋白(a)、脂联素（ADN）、抵抗素、瘦素、高敏反应蛋白（Hs-CRP）、肿瘤坏死因子- α (tnf - α)、视黄醇结合蛋白-4 （RBP-4）、脂素、vaspin、visfatin、omentin-1、趋化素。经过8年的观察，429例患者血糖维持正常，133例患者血糖异常，90例患者发生糖尿病。在血糖异常患者中，与基线相比，ADN较低，抵抗素较高，而在糖尿病患者中，ADN较低，抵抗素均高于基线，与正常血糖和血糖异常患者相比。与基线相比，高敏c反应蛋白、tnf - α在血糖异常和糖尿病患者中均较高，但在糖尿病患者中记录的数值均高于血糖正常和血糖异常患者。与基线和血糖正常的糖尿病患者相比，Visfatin升高，网膜蛋白1降低。优势比显示，低水平的脂联素和高水平的抵抗素，而不是其他细胞因子，增加了患2型糖尿病的风险。数据似乎表明，较低水平的脂联素和较高水平的抵抗素可以预测肥胖人群未来的糖尿病，甚至在疾病发病前几年。
The aim of this study was to valuate if there are some differences in metabolic parameters among obese which will develop diabetes and those that will not develop diabetes.We enrolled 959 obese, normal glucose tolerant, of either sex, outpatients and evaluated them for 8 years. We evaluated: body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment (HOMA) index, blood pressure, lipid profile, lipoprotein(a), adiponectin (ADN), resistin, leptin, high sensitivity reactive protein (Hs-CRP), tumor necrosis factor-alpha (TNF-alpha), retinol binding protein-4 (RBP-4), adipsin, vaspin, visfatin, omentin-1, chemerin.After 8 years of observation, 429 patients maintained euglycemia, while 133 patients developed dysglycemia, and 90 developed diabetes. In dysglycemic patients, ADN was lower, and resistin was higher compared to baseline, while in diabetic patients ADN was lower, and resistin was higher both compared to baseline, and compared to euglycemic and dysglycemic patients. High sensitivity C-reactive protein, TNF-alpha were higher in both dysglycemic and diabetic patients compared to baseline, but the values recorded in diabetics were higher both compared to euglycemic and dysglycemic. Visfatin was higher and omentin-1 was lower compared to baseline, and compared to euglycemic patients in diabetics. Odds ratio showed that lower levels of adiponectin and higher levels of resistin, but not of other cytokines, increased the risk of developing type 2 diabetes mellitus.Data seem to suggest that lower levels of adiponectin, and higher levels of resistin can be predictive of a future diabetes in obese people, even years before the disease onset.