The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors.
The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors.
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DOI：
10.2174/1389201011314030006
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发表时间：
2013
影响因子：
2.8
通讯作者：
Kridel SJ
中科院分区：
文献类型：
--
作者：
Deford-Watts LM;Mintz A;Kridel SJ
正电子发射断层扫描(PET)是一种分子成像手段，它提供了快速和非侵入性地显示来自多个器官的肿瘤的机会。为了做到这一点，PET利用放射性示踪剂，如18F-FDG和11C-乙酸酯，其摄取与肿瘤内改变的代谢途径一致。脂肪酸合成途径中酶的表达和活性增加是癌细胞的一个常见标志。因此，这一途径已成为治疗干预的主要靶点。尽管已经开发了多种直接或间接干扰脂肪酸合成的药物，但缺乏评估其有效性的最佳手段。鉴于11C-乙酸酯直接与脂肪酸合成途径相连，该探针为通过PET监测造脂肿瘤提供了独特的机会。在这里，我们回顾了脂肪酸合成途径在癌症中的相关性。此外，我们讨论了11C-乙酸酯PET在肿瘤成像中的潜在用途，特别是那些不是FDG-Avid的肿瘤。最后，我们讨论了可以从11C-乙酸酯PET中受益的几种治疗干预措施，以监测某些类型癌症患者的治疗反应。
Positron emission tomography (PET) is a molecular imaging modality that provides the opportunity to rapidly and non-invasively visualize tumors derived from multiple organs. In order to do so, PET utilizes radiotracers, such as 18F-FDG and 11C-acetate, whose uptake coincides with altered metabolic pathways within tumors. Increased expression and activity of enzymes in the fatty acid synthesis pathway is a frequent hallmark of cancer cells. As a result, this pathway has become a prime target for therapeutic intervention. Although multiple drugs have been developed that both directly and indirectly interfere with fatty acid synthesis, an optimal means to assess their efficacy is lacking. Given that 11C-acetate is directly linked to the fatty acid synthesis pathway, this probe provides a unique opportunity to monitor lipogenic tumors by PET. Herein, we review the relevance of the fatty acid synthesis pathway in cancer. Furthermore, we address the potential utility of 11C-acetate PET in imaging tumors, especially those that are not FDG-avid. Last, we discuss several therapeutic interventions that could benefit from 11C-acetate PET to monitor therapeutic response in patients with certain types of cancers.