THE PRESENCE OF ANTICARCINOEMBRYONIC ANTIGEN (CEA) ANTIBODIES IN THE SERA OF PATIENTS WITH GASTROINTESTINAL MALIGNANCIES
THE PRESENCE OF ANTICARCINOEMBRYONIC ANTIGEN (CEA) ANTIBODIES IN THE SERA OF PATIENTS WITH GASTROINTESTINAL MALIGNANCIES
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DOI：
10.1007/bf01540984
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发表时间：
1994-09-01
影响因子：
9.1
通讯作者：
GOLEMATIS, B
中科院分区：
文献类型：
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作者：
KONSTADOULAKIS, MM;SYRIGOS, KN;GOLEMATIS, B
我们用酶联免疫法检测了71例消化系统肿瘤患者、35例各种非恶性疾病患者和28例正常人血清中的抗CEA活性。在51%的患者血清中发现了抗体。大多数抗体阳性的患者（70%）没有转移性疾病的证据。来自对照组的少于10%的血清具有抗CEA活性。作者得出结论，患有GI系统癌症的患者能够产生肿瘤特异性抗体。这些抗体可用作肿瘤标志物和/或作为免疫系统功能的可能指标。大肿瘤块的存在可能导致这些抗体从循环中清除。
Using an enzyme-linked immunoassay we tested the sera of 71 patients with digestive system cancer, 35 patients with various nonmalignant disorders, and 28 normal individuals for anti-CEA activity. Antibodies were found in the sera of 51% of the patients. Most of the patients positive for the antibodies (70%) had no evidence of metastatic disease. Fewer than 10% of the sera from control groups had anti-CEA activity. The authors concluded that the patients suffering from cancer of the GI system are capable of producing tumor-specific antibodies. These antibodies could be used as a tumor marker and/or as a possible index for the function of the immune system. The presence of a large tumor mass could lead to the removal of these antibodies from the circulation.