Abnormal cortical activation during an auditory word comprehension task in benign childhood epilepsy with centrotemporal spikes: A magnetoencephalographic study
Abnormal cortical activation during an auditory word comprehension task in benign childhood epilepsy with centrotemporal spikes: A magnetoencephalographic study
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DOI：
10.1016/j.yebeh.2018.05.035
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发表时间：
2018-10-01
影响因子：
2.6
通讯作者：
Taniike, Masako
中科院分区：
文献类型：
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作者：
Kagitani-Shimono, Kuriko;Kato, Yoko;Taniike, Masako
目的：良性儿童癫痫伴中央颞区棘波（BECTS），也称为罗兰癫痫，最近有报道与不同程度的认知功能障碍有关。许多研究报告说，与健康对照组儿童相比，BECTS儿童的语言能力较差。为了阐明BECTS对语言认知的有害影响，我们研究了听觉语言理解task.Methods：参与者（N = 20），包括10名儿童诊断为BECTS（年龄10.8 +/- 2.8岁）和10名年龄匹配的健康儿童（对照组）（年龄10.6 +/- 1.6岁）引起的脑磁活动。使用一般智力功能和语言能力评估认知功能。在BECTS患者中，我们回顾了临床病程和脑电图（EEG）结果。我们用脑磁图（MEG）记录了听觉语言理解任务引起的皮层反应。结果：采用韦氏儿童智力量表（第4版）测定的全量表智商（FSIQ），BELTS组（96.4 ± 123）显著低于对照组（110.0 ± 7.4）。在一半的BECTS组中，听觉理解得分低于年龄标准水平。在BECTS组中，与对照组相比，任务期间的皮层激活在语言相关区域，如双侧初级听觉皮层，左侧上级和中间颞区，以及额叶下部区域显示出降低的强度。BECTS组左侧上级颞叶皮层激活与锋电位频率呈负相关，与FSI呈正相关。相反，在BECIS组中，右下额叶和颞中区的激活增加。从时间频率分析，低伽马带事件相关的desertification减少组BEM。结论：癫痫棘波负性影响语言相关皮层的听觉语言理解任务的反应。这些发现表明癫痫棘波可能对罗兰区的功能活动产生负面影响，并成为改变语言网络功能发育的原因。(C)2018爱思唯尔公司All rights reserved.
Objective: Benign childhood epilepsy with centrotemporal spikes (BECTS), also known as rolandic epilepsy, has recently been reported to be associated with variable degrees of cognitive dysfunction. Many studies reported poor language ability in children with BECTS compared with healthy control children. To elucidate the harmful effects of BECTS on language cognition, we studied the magnetoencephalographic activity elicited by an auditory language comprehension task.Methods: The participants (N = 20) included 10 children diagnosed with BECTS (aged 10.8 +/- 2.8 years) and 10 age-matched healthy children (control) (aged 10.6 +/- 1.6 years). Cognitive function was assessed using general intellectual function and language ability. In patients with BECTS, we reviewed the clinical course and electroencephalogram (EEG) findings. We recorded the cortical responses elicited by an auditory language comprehension task using magnetoencephalography (MEG). We compared those results between groups and analyzed the correlation with cognitive scores and frequency of spikes.Results: The full-scale intelligence quotient (FSIQ) by the Wechsler Intelligence Scale for Children-4th edition was significantly reduced in the group with BELTS (96.4 +/- 123) compared with the control group (110.0 +/- 7.4). In half of the group with BECTS, the auditory comprehension score fell below the age-standard level. In the group with BECTS, the cortical activation during the task showed reduced intensity in language-associated areas such as the bilateral primary auditory cortex, left superior and mid-temporal areas, and inferior frontal area compared with those in the control group. In addition, the cortical activation in the left superior temporal area was negatively correlated with spike frequency and positively correlated with FSIQin the group with BECTS. Conversely, the right inferior frontal and mid-temporal areas had increased the activations in the group with BECIS. From the time frequency analysis, low gamma band event-related desynchronization was reduced in the group with BEM.Conclusion: Epileptic spikes negatively influenced responsiveness to the auditory language comprehension task in the language-associated cortices. These findings suggest that epileptic spikes could have a negative impact on the functional activity in rolandic areas and become a reason to change the functional development of the language network. (C) 2018 Elsevier Inc. All rights reserved.