Copper-Catalyzed Asymmetric Synthesis of Bicyclo[3.n.1]alkenones.
Copper-Catalyzed Asymmetric Synthesis of Bicyclo[3.n.1]alkenones.
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DOI：
10.1021/acs.joc.1c00146
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发表时间：
2021-03
期刊：
影响因子：
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通讯作者：
Zhehui Liao;Jiantao Zhang;Tongxiang Cao;Shifa Zhu
中科院分区：
文献类型：
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作者：
Zhehui Liao;Jiantao Zhang;Tongxiang Cao;Shifa Zhu
通过铜催化的形式[3+3]环加成反应，以良好到优异的对映体选择性和中等到良好的产率成功地合成了一系列高度应变的双环[3.n.1]烯酮。这些用途广泛的手性环加合物可以选择性地转化为各种有价值的桥联体系，在构建含有[3.n.1]部分的天然和生物活性化合物方面具有相当大的潜力。
A series of highly strained bicyclo[3.n.1]alkenones have been successfully constructed in good-to-excellent enantioselectivities and moderate-to-good yields via copper-catalyzed formal [3+3] cycloaddition. The versatile chiral cycloadducts could be selectively converted into various valuable bridge systems, which hold considerable potential for the construction of natural and bioactive compounds containing a [3.n.1] moiety.