COMPOSITIONAL CONSTRAINTS AND GENOME EVOLUTION
COMPOSITIONAL CONSTRAINTS AND GENOME EVOLUTION
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DOI：
10.1007/bf02099946
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发表时间：
1986-01-01
影响因子：
3.9
通讯作者：
BERNARDI, G
中科院分区：
文献类型：
--
作者：
BERNARDI, G;BERNARDI, G
所有基因组的核苷酸序列都受到组成限制，这些限制（1）在大致相同的程度上影响编码和非编码序列;（2）不仅影响基因组的结构和功能，而且影响转录本和蛋白质的结构和功能;（3）是环境压力的结果;（4）在很大程度上控制突变的固定。这些发现表明：（1）非编码序列与生物学功能相关;（2）生物体表型包括两个组成部分，经典表型（对应于“基因产物”）和“基因组表型”（由组成约束定义）;（3）自然选择在基因组进化中起着比随机事件更重要的作用。
Nucleotide sequences of all genomes are subject to compositional constraints that (1) affect, to about the same extent, both coding and noncoding sequences; (2) influence not only the structure and function of the genome, but also those of transcripts and proteins; (3) are the result of environmental pressures; and (4) largely control the fixation of mutations. These findings indicate (1) that noncoding sequences are associated with biological functions; (2) that the organismal phenotype comprises two components, the classical phenotype, corresponding to the "gene products," and a "genome phenotype," which is defined by the compositional constraints; and (3) that natural selection plays a more important role in genome evolution than do random events.