Spatial profile and differential recruitment of GABAB modulate oscillatory activity in auditory cortex.
Spatial profile and differential recruitment of GABAB modulate oscillatory activity in auditory cortex.
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DOI：
10.1523/jneurosci.1703-09.2009
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发表时间：
2009-08-19
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影响因子：
--
通讯作者：
Reyes AD
中科院分区：
文献类型：
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作者：
Oswald AM;Doiron B;Rinzel J;Reyes AD
抑制和兴奋之间的相互作用是皮质网络活动的核心。在许多皮质中，包括听觉皮层 (ACx)，兴奋性神经元和抑制性神经元之间的相互作用会产生同步网络伽马振荡 (30-70 Hz)。在这里，我们表明，兴奋-抑制微电路的连接模式和突触特性的差异允许网络输入的空间范围调节伽马振荡的幅度。小鼠 ACx 切片 L2/3 中连接的快速尖峰 (FS) 中间神经元和锥体细胞 (PC) 的同时多个全细胞记录表明，对于体间距离 <50 µm，大多数抑制连接发生在相互连接 (RC) 对中；在更远的距离上，RC 和非互惠连接 (nRC) 对中抑制连接的可能性相同。此外，RC 对中 GABAB 介导的抑制作用弱于 nRC 对。仅当网络输入被限制在一个小区域时，包含这些特征的网络模型的模拟才显示出强烈的伽马带振荡。这些发现提出了一种新的机制，通过该机制可以通过调整传入输入的空间分布来调节振荡活动。
The interplay between inhibition and excitation is at the core of cortical network activity. In many cortices, including auditory cortex (ACx), interactions between excitatory and inhibitory neurons generate synchronous network gamma oscillations (30–70 Hz). Here, we show that differences in the connection patterns and synaptic properties of excitatory-inhibitory microcircuits permit the spatial extent of network inputs to modulate the magnitude of gamma oscillations. Simultaneous multiple whole-cell recordings from connected fast-spiking (FS) interneurons and pyramidal cells (PC) in L2/3 of mouse ACx slices revealed that for intersomatic distances <50 µm, most inhibitory connections occurred in reciprocally connected (RC) pairs; at greater distances, inhibitory connections were equally likely in RC and non-reciprocally connected (nRC) pairs. Furthermore, the GABAB mediated inhibition in RC pairs was weaker than in nRC pairs. Simulations with a network model that incorporated these features showed strong, gamma-band oscillations only when the network inputs were confined to a small area. These findings suggest a novel mechanism by which oscillatory activity can be modulated by adjusting the spatial distribution of afferent input.