Ligand-accelerated Pd-catalyzed ketone γ-arylation via C-C cleavage with aryl chlorides.
Ligand-accelerated Pd-catalyzed ketone γ-arylation via C-C cleavage with aryl chlorides.
复制标题
DOI：
10.1021/ol300119u
复制
发表时间：
2012-02
期刊：
影响因子：
5.2
通讯作者：
Asraa Ziadi;R. Martín
中科院分区：
文献类型：
--
作者：
Asraa Ziadi;R. Martín
提出了一种通过 C-C 键断裂的 Pd 催化环丁醇的高效芳基化扩环方法。该方法允许在低催化剂负载量下将芳基氯与多种官能团和取代模式偶联，从而构成制备相当难以捉摸的γ-芳基化酮的直接替代方案。
A highly efficient Pd-catalyzed arylative ring expansion of cyclobutanols via C-C bond cleavage is presented. The method allows the coupling of aryl chlorides at low catalyst loadings with a wide range of functional groups and substitution patterns, thus constituting a straightforward alternative for preparing rather elusive γ-arylated ketones.