Brain Structural Networks in Mouse Exposed to Chronic Maternal Undernutrition
Brain Structural Networks in Mouse Exposed to Chronic Maternal Undernutrition
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DOI：
10.1016/j.neuroscience.2018.03.049
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发表时间：
2018-06-01
期刊：
影响因子：
3.3
通讯作者：
Gonzalez, Paula N.
中科院分区：
文献类型：
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作者：
Barbeito-Andres, Jimena;Gleiser, Pablo M.;Gonzalez, Paula N.
已知在宫内生长受限和早产的情况下，大脑结构连接会发生改变，尽管母体营养限制的具体影响（人类的常见负担）尚未得到评估。在这里，我们通过建立三个实验组的雌性小鼠分为根据他们的饮食：控制（CO），中等热量蛋白质限制（MCP）和严重的蛋白质限制（SP）的母亲在怀孕和哺乳期间营养不良的影响进行分析。营养限制的母鼠在怀孕期间体重增加相对较少，后代的体重也受到母体营养不良的影响，显示出整体生长受限。我们在断奶后对后代的大脑进行了磁共振成像（MRI），并使用复杂的图论分析了它们的连接模式。在一般情况下，观察到的变化MCP组比SP更微妙。结果表明，大脑结构不均匀的影响，早期营养应激。特别是，中央脑区的生长，如颞顶叶皮质，和长的综合性有髓神经束相对保留，而短束的频率相对减少。我们还发现了不同的网络参数的影响：网络度，聚类，特征路径长度和小世界性基本保持不变，而丰富的俱乐部指数较低的营养限制的动物。富人俱乐部的减少反映了大脑结构的损伤，通过这种结构，拥有大量连接的大脑区域往往彼此之间联系得更紧密。总的来说，这里提出的研究结果支持了慢性营养应激导致大脑结构连接长期变化的假设。(c)2018年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Brain structural connectivity is known to be altered in cases of intrauterine growth restriction and premature birth, although the specific effect of maternal nutritional restriction, a common burden in human populations, has not been assessed yet. Here we analyze the effects of maternal undernutrition during pregnancy and lactation by establishing three experimental groups of female mice divided according to their diet: control (Co), moderate calorie-protein restriction (MCP) and severe protein restriction (SP). Nutritionally restricted dams gained relatively less weight during pregnancy and the body weight of the offspring was also affected by maternal undernutrition, showing global growth restriction. We performed magnetic resonance imaging (MRI) of the off-spring's brains after weaning and analyzed their connectivity patterns using complex graph theory. In general, changes observed in the MCP group were more subtle than in SP. Results indicated that brain structures were not homogeneously affected by early nutritional stress. In particular, the growth of central brain regions, such as the temporo-parietal cortex, and long integrative myelinated tracts were relatively preserved, while the frequency of short tracts was relatively reduced. We also found a differential effect on network parameters: network degree, clustering, characteristic path length and small-worldness remained mainly unchanged, while the rich-club index was lower in nutritionally restricted animals. Rich-club decrease reflects an impairment in the structure by which brain regions with large number of connections tend to be more densely linked among themselves. Overall, the findings presented here support the hypothesis that chronic nutritional stress produces long-term changes in brain structural connectivity. (c) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.