The extracellular matrix modulates fibroblast phenotype and function in the infarcted myocardium.
The extracellular matrix modulates fibroblast phenotype and function in the infarcted myocardium.
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DOI：
10.1007/s12265-012-9406-3
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发表时间：
2012-12
影响因子：
3.4
通讯作者：
Frangogiannis, Nikolaos G.
中科院分区：
文献类型：
--
作者：
Dobaczewski, Marcin;de Haan, Judith J.;Frangogiannis, Nikolaos G.
关键词：
心脏成纤维细胞是心脏修复的关键效应细胞；它们的表型和功能通过与细胞外基质蛋白的相互作用而调节。本文综述了细胞外基质对梗死心肌成纤维细胞炎症和修复特性的影响。梗死早期产生的基质片段诱导促炎和基质降解成纤维细胞表型。纤维蛋白/纤维连接蛋白丰富的临时基质的形成作为成纤维细胞迁移到梗死区域的通道。ED-A纤维连接蛋白和非纤维性胶原的诱导可能有助于肌成纤维细胞的转分化。基质细胞蛋白的上调促进了生长因子和细胞因子介导信号的转导。随着瘢痕的成熟，基质交联、基质细胞蛋白的清除和生长因子信号的减少导致修复性梗死成纤维细胞的失活和凋亡。了解基质成分对梗死成纤维细胞的影响可以指导设计复制或抑制特定基质细胞功能的肽，从而减轻不良重构。
Cardiac fibroblasts are key cellular effectors of cardiac repair; their phenotype and function are modulated by interactions with extracellular matrix proteins. This review manuscript discusses the effects of the extracellular matrix on the inflammatory and reparative properties of fibroblasts in the infarcted myocardium. Early generation of matrix fragments in the infarct induces a pro-inflammatory and matrix-degrading fibroblast phenotype. Formation of a fibrin/fibronectin-rich provisional matrix serves as a conduit for migration of fibroblasts into the infarcted area. Induction of ED-A fibronectin and non-fibrillar collagens may contribute to myofibroblast transdifferentiation. Upregulation of matricellular proteins promotes transduction of growth factor and cytokine-mediated signals. As the scar matures, matrix cross-linking, clearance of matricellular proteins and reduced growth factor signaling cause deactivation and apoptosis of reparative infarct fibroblasts. Understanding the effects of matrix components on infarct fibroblasts may guide the design of peptides that reproduce, or inhibit, specific matricellular functions, attenuating adverse remodeling.
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影响因子：
20.1
作者：
Frangogiannis NG
通讯作者：
Frangogiannis NG
DOI：
10.2353/ajpath.2010.090759
发表时间：
2010-05
期刊：
The American journal of pathology
影响因子：
--
作者：
Dobaczewski M;Xia Y;Bujak M;Gonzalez-Quesada C;Frangogiannis NG
通讯作者：
Frangogiannis NG
DOI：
10.1152/ajpheart.2001.281.3.h987
发表时间：
2001-09-01
影响因子：
4.8
作者：
Etoh, T;Joffs, C;Spinale, FG
通讯作者：
Spinale, FG
DOI：
10.1152/ajpheart.00514.2007
发表时间：
2007-09-01
影响因子：
4.8
作者：
Banerjee, Indroneal;Fuseler, John W.;Baudino, Troy A.
通讯作者：
Baudino, Troy A.
影响因子：
20.1
作者：
Bujak M;Dobaczewski M;Gonzalez-Quesada C;Xia Y;Leucker T;Zymek P;Veeranna V;Tager AM;Luster AD;Frangogiannis NG
通讯作者：
Frangogiannis NG