Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus
Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus
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DOI：
10.1016/j.micinf.2010.04.013
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发表时间：
2010-09-01
影响因子：
5.8
通讯作者：
Kido, Hiroshi
中科院分区：
文献类型：
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作者：
Takahashi, Etsuhisa;Kataoka, Kosuke;Kido, Hiroshi
抗病毒神经氨酸酶抑制剂奥司他韦(OSV)在流感治疗中被广泛用于抑制病毒复制。在这里，我们报告了OSV给药显著抑制了与抗原(Ag)特异性抗体(Ab)产生有关的呼吸道粘膜分泌性IgA反应，也抑制了Ag特异性IgA抗体形成细胞的诱导，但不能抑制全身免疫球蛋白反应，作为儿童流感模型。口服OSV组小鼠的气道液中和活性明显低于假手术组。我们的研究结果表明，OSV治疗后粘膜反应低的患者有再次感染的风险。(C)2010年爱思唯尔·马森公司。版权所有。
The antiviral neuraminidase inhibitor oseltamivir (OSV) is widely used to suppress viral replication in the treatment of influenza. Here, we report that OSV administration significantly suppressed respiratory mucosal secretory IgA responses with respect to antigen (Ag)-specific antibody (Ab) production and also the induction of Ag-specific IgA Ab-forming cells, but not systemic IgG responses, in weanling mice as a model of pediatric influenza. Neutralizing activities of the airway fluids in oral OSV-treated mice were significantly less than those of sham-treated mice. Our findings suggest the risk of re-infection in patients showing a low mucosal response following OSV treatment. (C) 2010 Elsevier Masson SAS. All rights reserved.