Role of bioactive fatty acids in nonalcoholic fatty liver disease.
Role of bioactive fatty acids in nonalcoholic fatty liver disease.
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DOI：
10.1186/s12937-016-0191-8
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发表时间：
2016-08-02
影响因子：
5.4
通讯作者：
Barbero-Becerra VJ
中科院分区：
文献类型：
--
作者：
Juárez-Hernández E;Chávez-Tapia NC;Uribe M;Barbero-Becerra VJ
非酒精性脂肪性肝病（NAFLD）的特征是肝细胞中的脂肪沉积，并与营养因素密切相关。膳食脂肪酸根据其生物化学性质进行分类，这些性质赋予其生物活性作用。单不饱和脂肪酸在各种人类和小鼠模型中具有双重作用。相反，多不饱和脂肪酸具有抗肥胖、抗脂肪变性和抗炎作用。根据饮食类型、每日摄入量和n-6与n-3脂肪的比例，这些脂肪酸形式的组合会损害肝脏脂质代谢。生物活性脂肪酸的化学感受作用而非营养作用使其成为NAFLD的可能生物标志物。生物活性脂肪酸通过改变脂肪酸组成和调节肝纤维化期间肝细胞的活性来提供健康益处。需要更多更好的证据来阐明生物活性脂肪酸在NAFLD患者营养和临床治疗策略中的作用。
Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. In contrast, polyunsaturated fatty acids exhibit antiobesity, anti steatosic and anti-inflammatory effects. The combination of these forms of fatty acids—according to dietary type, daily intake and the proportion of n-6 to n-3 fats—can compromise hepatic lipid metabolism. A chemosensory rather than a nutritional role makes bioactive fatty acids possible biomarkers for NAFLD. Bioactive fatty acids provide health benefits through modification of fatty acid composition and modulating the activity of liver cells during liver fibrosis. More and better evidence is necessary to elucidate the role of bioactive fatty acids in nutritional and clinical treatment strategies for patients with NAFLD.