Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study
Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study
复制标题
DOI：
10.1530/eje-07-0893
复制
发表时间：
2008-06-01
影响因子：
5.8
通讯作者：
Yeap, Bu B.
中科院分区：
文献类型：
--
作者：
Chubb, S. A. Paul;Hyde, Zoe;Yeap, Bu B.
背景：循环中睾酮和性激素结合球蛋白（SHBG）的减少是代谢综合征的危险因素。由于SHBG随着年龄的增长而增加，而睾酮下降，我们研究了SHBG和睾酮对老年男性代谢综合征风险的相对贡献。方法：我们对2502名年龄≥ 70岁的社区居住男性进行了横断面研究，没有已知的糖尿病。代谢综合征的定义采用国家胆固醇教育计划-第三成人治疗小组（NCEP-ATP III）标准。清晨空腹血清测定总睾酮，SHBG和LH。结果：代谢综合征患者602例（24.1%）。总睾酮< 20 nmol/l、SHBG < 50 nmol/l和游离睾酮< 300 pmol/l时，代谢综合征的风险增加。在单变量分析中，SHBG与代谢综合征的所有五个组成部分相关，总睾酮与除高血压外的所有组成部分相关，游离睾酮仅与腰围和甘油三酯相关。在多变量分析中，总睾酮和特别是SHBG仍然与代谢综合征相关。比值比分别为1.34（95%可信区间（CI）：1.18-1.52）和1.77（95%，CI：1.53-2.06）
Background: Reduced circulating testosterone and sex hormone-binding globulin (SHBG) Eire implicated as risk factors for metabolic syndrome. As SHBG increases with age while testosterone declines, we examined the relative contributions of SHBG and testosterone to the risk of metabolic syndrome in older men.Methods: We conducted a cross-sectional study of 2502 community-dwelling men aged >= 70 years without known diabetes. Metabolic syndrome was defined using the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATPIII) criteria. Early morning fasting sera were assayed for total testosterone, SHBG and LH. Free testosterone was calculated using mass action equations.Results: There were 602 men with metabolic syndrome (24.1%). The risk of metabolic syndrome increased for total testosterone < 20 nmol/l, SHBG < 50 nmol/l and free testosterone < 300 pmol/l. In univariate analyses SHBG was associated with all five components of metabolic syndrome, total testosterone was associated with all except hypertension, and free testosterone was associated only with waist circumference and triglycerides. In multivariate analysis, both total testosterone and especially SHBG remained associated with metabolic syndrome. with odds ratios of 1.34 (95% confidence interval (Cl): 1.18-1.52) and 1.77 (95%, Cl: 1.53-2.06) respectively Men with hypogonadotrophic hypogonadism (total testosterone < 8 nmol/l, LH