Diffusion Tensor Tractography of the Human Brain Cortico-Ponto-Cerebellar Pathways: A Quantitative Preliminary Study
Diffusion Tensor Tractography of the Human Brain Cortico-Ponto-Cerebellar Pathways: A Quantitative Preliminary Study
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DOI：
10.1002/jmri.22330
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发表时间：
2010-10-01
影响因子：
4.4
通讯作者：
Hasan, Khader M.
中科院分区：
文献类型：
--
作者：
Kamali, Arash;Kramer, Larry A.;Hasan, Khader M.
目的：探讨实用的扩散张量纤维束成像在1毫米切片厚度映射和量化的整个轨迹不同的皮质-桥脑-小脑途径的健康成人brain.Materials和方法：这项工作是由当地机构审查委员会批准，并符合健康保险便携性和责任法案（HIPAA）。研究了5名健康的右利手男性（年龄范围，24-37岁），并获得了书面知情同意书。在3.0特斯拉（T）临床MRI扫描仪上以1 mm层厚采集的扩散张量成像数据进行准备，并使用纤维束成像方法进行分析，以重建皮质-桥脑-小脑通路，包括额桥脑-小脑、顶桥脑-小脑、枕桥脑-小脑和颞桥脑-小脑束。我们证明的可行性tracgraphic映射和量化的四个皮质-桥脑-小脑系统的组成部分的基础上，他们的皮质连接在健康的人脑中使用DTI数据薄1毫米切片。在3.0T下使用1 mm切片，基于皮质连接的不同皮质-桥脑-小脑通路的体内定量是可行的。
Purpose: To investigate the utility of diffusion tensor tractography at 1 mm slice thickness to map and quantify the whole trajectory of different cortico-ponto-cerebellar pathways of the healthy adult human brain.Materials and Methods: This work was approved by the local Institutional Review Board, and was Health Insurance Portability and Accountability Act (HIPAA) compliant. Five healthy right-handed men (age range, 24-37 years) were studied and written informed consent was obtained. Diffusion tensor imaging data acquired with 1-mm slice thickness at a 3.0 Tesla (T) clinical MRI scanner were prepared and analyzed using tractography methods to reconstruct the cortico-ponto-cerebellar pathways which included the fronto-ponto-cerebellar, parieto-ponto-cerebellar, occipito-ponto-cerebellar, and temporo-ponto-cerebellar tracts.Results: We demonstrate the feasibility of tractographic mapping and quantification of the four cortico-ponto-cerebellar system components based on their cortical connections in the healthy human brain using DTI data with thin 1-mm sections.Conclusion: In vivo quantification of different cortico-ponto-cerebellar pathways based on cortical connection is feasible, using 1-mm slices at 3.0T.