Roles of PPARs in health and disease
Roles of PPARs in health and disease
复制标题
DOI：
10.1038/35013000
复制
发表时间：
2000-05-25
期刊：
影响因子：
64.8
通讯作者：
Wahli, W
中科院分区：
文献类型：
--
作者：
Kersten, S;Desvergne, B;Wahli, W
在发达社会，糖尿病、肥胖症、动脉粥样硬化和癌症等慢性疾病是造成大多数死亡的原因。这些疾病有复杂的原因，涉及遗传、环境和营养因素。有证据表明，一组密切相关的核受体，称为过氧化物酶体增殖物激活受体（PPARs），可能参与这些疾病。这一点，再加上PPAR活性可以通过药物如噻唑烷二酮类和贝特类调节的事实，激发了对PPARs的大量研究工作（1）。在这里，我们提出了在PPARs领域的最新进展，特别强调在各种营养状态下PPARs的生理功能，以及PPARs在几种慢性疾病中的可能作用。
In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research effort into PPARs(1). Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.