Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning
Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning
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DOI：
10.1006/dbio.1998.8850
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发表时间：
1998-04-01
影响因子：
2.7
通讯作者：
Chuong, CM
中科院分区：
文献类型：
--
作者：
Jung, HS;Francis-West, PH;Chuong, CM
周期性模式的形成是生物学的基础。描述这些现象的理论模型已经提出了羽毛图案，但是，没有分子候选人已被确定。在这里，我们表明，羽毛道开始由一个连续的条纹的Shh，FGF-4，和Ptc在上皮细胞中的表达，然后分离成离散的羽毛原基，更强烈的Shh和FGF-4阳性。Bmp-2和Bmp-4也呈阳性。与诱导羽毛形成的激活剂SHH和FGF-4相比，BMPs的珠介导的递送抑制局部羽毛形成。FGF-4和SHH均诱导Bmp-4的局部表达，而BMP-Q抑制两者的局部表达。FGF-4也诱导Shh。基于这些发现，我们提出了一个模型，涉及（1）均匀分布的全球激活剂，定义的字段，（2）一个位置依赖的激活剂的能力，传播整个领域，（3）本地激活剂和抑制剂在个别原基的网站触发，在反应扩散机制。本文还提出了一个羽纹形成的计算机模拟模型。(C)北京：科学出版社.
The formation of periodic patterns is fundamental in biology. Theoretical models describing these phenomena have been proposed for feather patterning; however, no molecular candidates have been identified. Here we show that the feather tract is initiated by a continuous stripe of Shh, Fgf-4, and Ptc expression in the epithelium, which then segregates into discrete feather primordia that are more strongly Shh and Fgf-4 positive. The primordia also become Bmp-2 and Bmp-4 positive. Bead-mediated delivery of BMPs inhibits local feather formation in contrast with the activators, SHH and FGF-4, which induce feather formation. Both FGF-4 and SHH induce local expression of Bmp-4, while BMP-Q suppresses local expression of both. FGF-4 also induces Shh. Based on these findings, we propose a model that involves (1) homogeneously distributed global activators that define the field, (2) a position-dependent activator of competence that propagates across the field, and (3) local activators and inhibitors triggered in sites of individual primordia that act in a reaction-diffusion mechanism. A computer simulation model for feather pattern formation is also presented. (C) 1998 Academic Press.