Interferon signaling restrains renal cell carcinoma heterogeneity.
Interferon signaling restrains renal cell carcinoma heterogeneity.
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干扰素信号传导抑制肾细胞癌的异质性。
DOI：
10.1016/j.trecan.2023.08.008
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发表时间：
2023
期刊：
影响因子：
18.4
通讯作者：
Galluzzi,Lorenzo
中科院分区：
文献类型：
--
作者：
Holicek,Peter;Fucikova,Jitka;Galluzzi,Lorenzo
I 型干扰素 (IFN) 是癌症监测的核心，因为它介导直接和免疫介导的肿瘤抑制作用。 Perelli 等人最近的一项研究。表明肾癌细胞耐受染色体不稳定性 (CIN) 引起的复杂核型改变并最终获得完全转移潜力的能力也受到 IFN 信号传导的负向调节。
Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.